| Presentation | 2015-12-19 Quantitative evaluation of White matter abnormalities in Schizophrenia based on an Automated Fiber-tracking Method with MR Diffusion Tensor Imaging. Hodaka Miki, Shiho Okuhata, Naohiro Okada, Noriaki Yahata, Kiyoto Kasai, Tetsuo Kobayashi, |
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| PDF Download Page |  PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | 【Objective】The number of schizophrenic patients in Japan is around 795 thousand and early detection and treatment would lead to long-term recovery. It is expected that quantitative evaluation of schizophrenic state through analyses of cerebral white matter integrity using nerve fiber tractography would help early detection of the disease. In order to clarify the physical fiber connections associated with disease specific neuronal circuits, we proposed an automated fiber tracking method using MR-DTIs and applied the method to schizophrenic patients.【Method】Based on a parcellation map that separating white matter into 54 regions, we proposed the following two methods. The first method automatically sets the starting surface of fiber tracking and the second method automatically rotates the surface. These methods were applied to MR-DTIs of 18 healthy controls and 18 schizophrenic patients. Next, we set 6 parameters (the number of fibers, the number of steps of fibers, the mean and standard deviation of FA, the mean and standard deviation of MD) for comparison between the two groups.【Result】Using two-way ANOVAs (Group / Hemisphere), we found significant differences in 17 white matters regions.【Conclusion】The possibility of identification of neural circuit that plays an important role about schizophrenia has been shown. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Schizophrenia / Magnetic Resonance Diffusion Tensor Imaging (MR-DTI) / Parcellation Map / Tractography |
| Paper # | MBE2015-81 |
| Date of Issue | 2015-12-12 (MBE) |
| Conference Information | |
| Committee | MBE / NC |
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| Conference Date | 2015/12/19(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | Nagoya Institute of Technology |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
| Chair | Tetsuo Kobayashi(Kyoto Univ.) / Toshimichi Saito(Hosei Univ.) |
| Vice Chair | Yutaka Fukuoka(Kogakuin Univ.) / Shigeo Sato(Tohoku Univ.) |
| Secretary | Yutaka Fukuoka(akita noken) / Shigeo Sato(Kogakuin Univ.) |
| Assistant | Takenori Oida(Kyoto Univ.) / Ryota Horie(Shibaura Inst. of Tech.) / Hiroyuki Kanbara(Tokyo Inst. of Tech.) / Hisanao Akima(Tohoku Univ.) |
| Paper Information | |
| Registration To | Technical Committee on ME and Bio Cybernetics / Technical Committee on Neurocomputing |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Quantitative evaluation of White matter abnormalities in Schizophrenia based on an Automated Fiber-tracking Method with MR Diffusion Tensor Imaging. |
| Sub Title (in English) | |
| Keyword(1) | Schizophrenia |
| Keyword(2) | Magnetic Resonance Diffusion Tensor Imaging (MR-DTI) |
| Keyword(3) | Parcellation Map |
| Keyword(4) | Tractography |
| 1st Author's Name | Hodaka Miki |
| 1st Author's Affiliation | Kyoto University(Kyoto Univ) |
| 2nd Author's Name | Shiho Okuhata |
| 2nd Author's Affiliation | Kyoto University(Kyoto Univ) |
| 3rd Author's Name | Naohiro Okada |
| 3rd Author's Affiliation | Tokyo University(Tokyo Univ) |
| 4th Author's Name | Noriaki Yahata |
| 4th Author's Affiliation | Tokyo University(Tokyo Univ) |
| 5th Author's Name | Kiyoto Kasai |
| 5th Author's Affiliation | Tokyo University(Tokyo Univ) |
| 6th Author's Name | Tetsuo Kobayashi |
| 6th Author's Affiliation | Kyoto University(Kyoto Univ) |
| Date | 2015-12-19 |
| Paper # | MBE2015-81 |
| Volume (vol) | vol.115 |
| Number (no) | MBE-383 |
| Page | pp.pp.107-112(MBE), |
| #Pages | 6 |
| Date of Issue | 2015-12-12 (MBE) |