| Presentation | 2015-07-31 Modeling the electrical impedance of a quartz crystal resonator sensor with the adsorption of molecular-targeted microbubbles and the verification experiment Yasuhiro Yokoi, Kenji Yoshida, Ryosuke Shimoya, Yoshiaki Watanabe, |
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| PDF Download Page |  PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Microbubbles (MBs), which specifically absorb to the target molecular, has been applied as the ultrasonic molecular imaging. Although it is important to understand the sensitivity of bubbles to the target molecules, the evaluation of the sensitivity is difficult in in-vivo experiment. We suggested the experimental system for evaluating the sensitivity of MBs using quartz crystal microbalance (QCM), and confirmed that resonance characteristics of QCM changes due to the specific adsorption of MBs. In this paper, we propose the physical model for calculating the number density and size of MBs on QCM surface based on the analysis of the change of motional impedance. We discuss whether the number density and size distribution of adsorbed bubbles could be estimated using our model-based analysis under the assumption that particle size distribution is known. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | QCM / resonant characteristics / streptavidin-biotin bond / targeting ability / microbubbles |
| Paper # | US2015-28 |
| Date of Issue | 2015-07-24 (US) |
| Conference Information | |
| Committee | US |
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| Conference Date | 2015/7/31(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | Nippon Paint Holdings |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | Material Proparty, General |
| Chair | Yoichi Ito(Nihon Univ.) |
| Vice Chair | Mami Matsukawa(Doshisha Univ.) / Nobuyuki Endoh(Kanagawa Univ.) |
| Secretary | Mami Matsukawa(Univ. of Electro-Comm.) / Nobuyuki Endoh(Univ. of Electro-Comm.) |
| Assistant | Hideyuki Hasegawa(Univ. of Toyama) |
| Paper Information | |
| Registration To | Technical Committee on Ultrasonics |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Modeling the electrical impedance of a quartz crystal resonator sensor with the adsorption of molecular-targeted microbubbles and the verification experiment |
| Sub Title (in English) | |
| Keyword(1) | QCM |
| Keyword(2) | resonant characteristics |
| Keyword(3) | streptavidin-biotin bond |
| Keyword(4) | targeting ability |
| Keyword(5) | microbubbles |
| 1st Author's Name | Yasuhiro Yokoi |
| 1st Author's Affiliation | Doshisha University(Doshisha Univ.) |
| 2nd Author's Name | Kenji Yoshida |
| 2nd Author's Affiliation | Chiba University(Chiba Univ.) |
| 3rd Author's Name | Ryosuke Shimoya |
| 3rd Author's Affiliation | Doshisha University(Doshisha Univ.) |
| 4th Author's Name | Yoshiaki Watanabe |
| 4th Author's Affiliation | Doshisha University(Doshisha Univ.) |
| Date | 2015-07-31 |
| Paper # | US2015-28 |
| Volume (vol) | vol.115 |
| Number (no) | US-168 |
| Page | pp.pp.7-12(US), |
| #Pages | 6 |
| Date of Issue | 2015-07-24 (US) |