| Presentation | 2015-06-11 Quantitative assessment of pacemaker activity generated by changing ionic currents in a ventricular cell model Yoshiki Ogawa, Shinji Doi, |
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| PDF Download Page |  PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | In ventricular cells, pacemaker activity is induced by changing ionic current on cell membrane, although those cells are intrinsically quiescent non-pacemaking cells. These artificial pacemaker cells created from quiescent cardiomyocytes are called biological pacemaker, which is expected as an alternative to electronic pacemaker. Since it is necessary for biological pacemaker engineering to understand the dynamics of various ion channels comprehensively, we use the mathematical cell model. By analyzing a human ventricular cell model, we have demonstrated pacemaker activity was generated by changing inward rectifier potassium current $I_{rm K1}$ and hyperpolarization-activated current $I_{rm f}$. In this report, we quantitatively evaluate the pacemaker activity generated from the ventricular cell by comparing with intact pacemaker cell. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | ventricular cell model / bifurcation analysis / biological pacemaker |
| Paper # | NLP2015-45,CCS2015-7 |
| Date of Issue | 2015-06-04 (NLP, CCS) |
| Conference Information | |
| Committee | NLP / CCS |
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| Conference Date | 2015/6/11(2days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | Waseda Univerisity |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
| Chair | Kenya Jinno(Nippon Inst. of Tech.) / Hiroo Sekiya(Chiba Univ.) |
| Vice Chair | Naoto Fujisaka(Hiroshima City Univ.) / Yasuhiro Tsubo(Ritsumeikan Univ.) / Naoki Wakamiya(Osaka Univ.) |
| Secretary | Naoto Fujisaka(Tokyo Univ. of Science) / Yasuhiro Tsubo(Konan Univ.) / Naoki Wakamiya(Kagawa National College of Tech.) |
| Assistant | Hidehiro Nakano(Tokyo City Univ.) / Hiroyuki Asahara(Okayama Univ. of Science) / Takayuki Kimura(Nippon Inst. of Tech.) / Song-Ju Kim(NIMS) / Ryo Takahashi(Kyoto Univ.) / Junnosuke Teramae(Osaka Univ.) |
| Paper Information | |
| Registration To | Technical Committee on Nonlinear Problems / Technical Committee on Complex Communication Sciences |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Quantitative assessment of pacemaker activity generated by changing ionic currents in a ventricular cell model |
| Sub Title (in English) | |
| Keyword(1) | ventricular cell model |
| Keyword(2) | bifurcation analysis |
| Keyword(3) | biological pacemaker |
| 1st Author's Name | Yoshiki Ogawa |
| 1st Author's Affiliation | Kyoto University(Kyoto Univ.) |
| 2nd Author's Name | Shinji Doi |
| 2nd Author's Affiliation | Kyoto University(Kyoto Univ.) |
| Date | 2015-06-11 |
| Paper # | NLP2015-45,CCS2015-7 |
| Volume (vol) | vol.115 |
| Number (no) | NLP-77,CCS-78 |
| Page | pp.pp.37-42(NLP), pp.37-42(CCS), |
| #Pages | 6 |
| Date of Issue | 2015-06-04 (NLP, CCS) |