| Presentation | 2024-03-11 An analysis of evoked-response dynamics with a simple synaptic plasticity model upon long-term depression in the auditory cortex Ryo Furukawa, Takashi Tateno, |
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| PDF Download Page |  PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | In the context of neurotransmitter receptors within the central nervous system, the efficient selection in advance of key candidates related to auditory cortical synaptic plasticity could enable us to perform physiological experiments more efficiently. Several simple models have already been proposed to describe the response dynamics after the induction of neural plasticity. Here, we initially measured cortical responses to electrical stimulation after inducing plasticity under several pharmacological conditions, manipulating both control and receptor-modulated groups. Subsequently, between the groups, we estimated and compared the coefficients of the dynamic model describing the electric-pulse-driven responses after the synaptic plasticity induction. Then, we discuss the main receptors involved in the neural plasticity of the auditory cortex, as elucidated by a simple model. Finally, drawing from the outcomes of this study, we discuss prospective challenges for future applied research. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Auditory cortex / Brain slice / Long-term depression / Synaptic plasticity model |
| Paper # | NC2023-47 |
| Date of Issue | 2024-03-04 (NC) |
| Conference Information | |
| Committee | NC / MBE |
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| Conference Date | 2024/3/11(2days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | The Univ. of Tokyo |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | Brain architecture, General |
| Chair | Hirokazu Tanaka(Tokyo City Univ.) / Hisashi Yoshida(Kinki Univ.) |
| Vice Chair | Jun Izawa(Univ. of Tsukub) / Akinori Ueno(Tokyo Denki Univ.) |
| Secretary | Jun Izawa(NTT) / Akinori Ueno(NAIST) |
| Assistant | Yoshimasa Tawatsuji(Waseda Univ.) / Takato Horii(Osaka Univ.) / Akihiko Tsukahara(Tokyo Denki Univ.) / Miki Kaneko(Osaka Univ.) |
| Paper Information | |
| Registration To | Technical Committee on Neurocomputing / Technical Committee on ME and Bio Cybernetics |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | An analysis of evoked-response dynamics with a simple synaptic plasticity model upon long-term depression in the auditory cortex |
| Sub Title (in English) | Exploration of major neurotransmitter receptors for an induction of depression |
| Keyword(1) | Auditory cortex |
| Keyword(2) | Brain slice |
| Keyword(3) | Long-term depression |
| Keyword(4) | Synaptic plasticity model |
| 1st Author's Name | Ryo Furukawa |
| 1st Author's Affiliation | Graduate School of Information Science and Technology, Hokkaido University(Hokkaido Univ.) |
| 2nd Author's Name | Takashi Tateno |
| 2nd Author's Affiliation | Faculty of Information Science and Technology, Hokkaido University(Hokkaido Univ.) |
| Date | 2024-03-11 |
| Paper # | NC2023-47 |
| Volume (vol) | vol.123 |
| Number (no) | NC-418 |
| Page | pp.pp.25-30(NC), |
| #Pages | 6 |
| Date of Issue | 2024-03-04 (NC) |