| Presentation | 2023-03-13 A mathematical model of competitive growth and pruning of dendritic spines in the postnatal development of neuronal receptive fields and orientation maps in the visual cortex Shigeru Tanaka, Masanobu Miyashita, |
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| PDF Download Page |  PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | In the cerebral cortex and hippocampus, synaptic contacts are made on axonal boutons rather than axon terminals, and synaptic plasticity is expressed by the dynamic changes in the cytoskeletal structure of dendritic spines. It is also proposed that the formation, growth and pruning of spines occur under the interaction mediated by Rho-GTPases diffusing among neighboring spines on the same dendrite. In the present study, we build a mathematical model of synaptic rewiring based on the interspine interaction and perform computer simulations to reproduce neurons’ receptive fields and orientation-direction joint maps in the visual cortex. Furthermore, we argue the changes of the total number of synapses on excitatory neurons during the critical period. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Synaptic plasticity / Dendritic spine / Orientation-direction maps / Molecular mechanisms / Self-organization model |
| Paper # | NC2022-92 |
| Date of Issue | 2023-03-06 (NC) |
| Conference Information | |
| Committee | NC / MBE |
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| Conference Date | 2023/3/13(3days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | The Univ. of Electro-Communications |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | Brain architecture, General |
| Chair | Hiroshi Yamakawa(Univ of Tokyo) / Junichi Hori(Niigata Univ.) |
| Vice Chair | Hirokazu Tanaka(Tokyo City Univ.) / Hisashi Yoshida(Kinki Univ.) |
| Secretary | Hirokazu Tanaka(NTT) / Hisashi Yoshida(NICT) |
| Assistant | Yoshimasa Tawatsuji(Waseda Univ.) / Tomoki Kurikawa(KMU) / Emi Yuda(Tohoku Univ) / Miki Kaneko(Osaka Univ.) |
| Paper Information | |
| Registration To | Technical Committee on Neurocomputing / Technical Committee on ME and Bio Cybernetics |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | A mathematical model of competitive growth and pruning of dendritic spines in the postnatal development of neuronal receptive fields and orientation maps in the visual cortex |
| Sub Title (in English) | |
| Keyword(1) | Synaptic plasticity |
| Keyword(2) | Dendritic spine |
| Keyword(3) | Orientation-direction maps |
| Keyword(4) | Molecular mechanisms |
| Keyword(5) | Self-organization model |
| 1st Author's Name | Shigeru Tanaka |
| 1st Author's Affiliation | National Institute of Technology, Numazu College(NIT Numazu College) |
| 2nd Author's Name | Masanobu Miyashita |
| 2nd Author's Affiliation | National Institute of Technology, Numazu College(NIT Numazu College) |
| Date | 2023-03-13 |
| Paper # | NC2022-92 |
| Volume (vol) | vol.122 |
| Number (no) | NC-425 |
| Page | pp.pp.7-12(NC), |
| #Pages | 6 |
| Date of Issue | 2023-03-06 (NC) |