| Presentation | 2022-06-17 Studies on ultrasonically and microbubble-induced blood-brain barrier opening using a gel capillary phantom Miryu Shinzato, Kato Yuji, Hashimoto Mamoru, Nobuki Kudo, |
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| PDF Download Page |  PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | DOX-Alb is albumin nanoparticles of approximately 160 nm in diameter with anticancer drug doxorubicin (DOX) adhering to their surfaces. DOX-Alb is used to deliver the drug to tumor tissue by intravascular injection of DOX-Alb with microbubbles and sonication. This study developed a capillary phantom with a 10 ?m diameter lumen using acrylamide gel to validate the basic idea method. An experiment to introduce DOX or DOX-Alb into the lumen confirmed that the phantom has the characteristics of diffusing low molecular weight DOX and retaining DOX-Alb nanoparticles inside the lumen, as in biological capillaries. Another experiment to irradiate the phantom by one-shot ultrasound burst pulse (1 MHz, 1 MPa in negative peat pressure, and 50 or 1,000 cycles) showed that bubble oscillation enhances DOX diffusion and induces lumen deformation and leakage of DOX-Alb. This phantom is expected to play an essential role in understanding the phenomena occurring in capillaries. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Ultrasound / microbubbles / drug delivery / capillary / gel phantom / nano particles |
| Paper # | MBE2022-10 |
| Date of Issue | 2022-06-10 (MBE) |
| Conference Information | |
| Committee | MBE / IEE-MBE |
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| Conference Date | 2022/6/17(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | Online |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | ME, etc. |
| Chair | Junichi Hori(Niigata Univ.) |
| Vice Chair | Hisashi Yoshida(Kinki Univ.) |
| Secretary | Hisashi Yoshida(Setsunan Univ) / (Tohoku Inst. of Tech.) |
| Assistant | Emi Yuda(Tohoku Univ) / Miki Kaneko(Osaka Univ.) |
| Paper Information | |
| Registration To | Technical Committee on ME and Bio Cybernetics / The Technical Committee on Medical and Biological Engineering |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Studies on ultrasonically and microbubble-induced blood-brain barrier opening using a gel capillary phantom |
| Sub Title (in English) | |
| Keyword(1) | Ultrasound |
| Keyword(2) | microbubbles |
| Keyword(3) | drug delivery |
| Keyword(4) | capillary |
| Keyword(5) | gel phantom |
| Keyword(6) | nano particles |
| 1st Author's Name | Miryu Shinzato |
| 1st Author's Affiliation | Hokkaido University(Hokkaido Univ.) |
| 2nd Author's Name | Kato Yuji |
| 2nd Author's Affiliation | Hokkaido University(Hokkaido Univ.) |
| 3rd Author's Name | Hashimoto Mamoru |
| 3rd Author's Affiliation | Hokkaido University(Hokkaido Univ.) |
| 4th Author's Name | Nobuki Kudo |
| 4th Author's Affiliation | Hokkaido University(Hokkaido Univ.) |
| Date | 2022-06-17 |
| Paper # | MBE2022-10 |
| Volume (vol) | vol.122 |
| Number (no) | MBE-82 |
| Page | pp.pp.12-12(MBE), |
| #Pages | 1 |
| Date of Issue | 2022-06-10 (MBE) |