| Presentation | 2021-11-19 Energy efficient control of bursts' rhythm in a mathematical model of the pancreatic beta cell Keita Koyama, Hiroyasu Ando, Kantaro Fujiwara, |
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| PDF Download Page |  PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Bursting activity of pancreatic beta cells are correlated with the function of insulin secretion. While normal pancreatic $beta$-cells show periodic bursting, the bursting activity becomes irregular in dysfunctional pancreatic $beta$-cells of type 2 diabetic patients. In this study, we reproduced the dynamics of dysfunctional pancreatic $beta$-cells using a mathematical model and investigated it in terms of the energy efficient control of burst's rhythm. The control method is considered for on-demand electrical stimulation in terms of the methodology of chaos control. As a result of numerical simulations, the bursts are controlled in periodic rhythm by a feedback input. In addition, we have found input timings that induce energy efficient control of bursts' rhythm. These results suggest that chaos control may improve the function of insulin secretion, which may contribute to the treatment of type 2 diabetes. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Pancreatic beta-cell / Mathematical model / Dysfunction / On-demand / Energy efficient / Control of chaos |
| Paper # | CCS2021-31 |
| Date of Issue | 2021-11-11 (CCS) |
| Conference Information | |
| Committee | CCS |
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| Conference Date | 2021/11/18(2days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | Osaka Univ. |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
| Chair | Tetsuya Asai(Hokkaido Univ.) |
| Vice Chair | Megumi Akai(Hokkaido Univ.) / Masaki Aida(TMU) |
| Secretary | Megumi Akai(TDK) / Masaki Aida(Mie Univ.) |
| Assistant | Hidehiro Nakano(Tokyo City Univ.) / Hiroyasu Ando(Tsukuba Univ.) / Takashi Matsubara(Osaka Univ.) / Sumiko Miyata(Shibaura Inst. of Tech.) |
| Paper Information | |
| Registration To | Technical Committee on Complex Communication Sciences |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Energy efficient control of bursts' rhythm in a mathematical model of the pancreatic beta cell |
| Sub Title (in English) | |
| Keyword(1) | Pancreatic beta-cell |
| Keyword(2) | Mathematical model |
| Keyword(3) | Dysfunction |
| Keyword(4) | On-demand |
| Keyword(5) | Energy efficient |
| Keyword(6) | Control of chaos |
| 1st Author's Name | Keita Koyama |
| 1st Author's Affiliation | University of Tsukuba(Univ. of Tsukuba) |
| 2nd Author's Name | Hiroyasu Ando |
| 2nd Author's Affiliation | Tohoku University/University of Tsukuba(Tohoku Univ./Univ. of Tsukuba) |
| 3rd Author's Name | Kantaro Fujiwara |
| 3rd Author's Affiliation | University of Tokyo(Univ. of Tokyo) |
| Date | 2021-11-19 |
| Paper # | CCS2021-31 |
| Volume (vol) | vol.121 |
| Number (no) | CCS-253 |
| Page | pp.pp.79-83(CCS), |
| #Pages | 5 |
| Date of Issue | 2021-11-11 (CCS) |