| Presentation | 2021-10-29 Computer simulations of colorectal tumor development Riku Ichinohe, Norihiro Katayama, Mitsuyuki Nakao, |
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| PDF Download Page |  PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | It is known that prevalence of colorectal cancer increases in work schedules that do not follow the circadian rhythm such as shift workers. In this study, we modeled the formation and maintenance mechanism of colonic epithelial tissue that repeats reorganization under the control of the central and peripheral circadian rhythm mechanisms. Based on this, we simulated the dynamics of tumor development by changing intensity of peripheral clock mechanism. Based on the results, we evaluate the carcinogenic risk and link it to proposals for lower-risk lifestyle habits. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Circadian ryhthm / Cell cycle / Intestinal cancer / Mathematical model |
| Paper # | MBE2021-23 |
| Date of Issue | 2021-10-21 (MBE) |
| Conference Information | |
| Committee | MBE / NC |
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| Conference Date | 2021/10/28(2days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | Online |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
| Chair | Ryuhei Okuno(Setsunan Univ.) / Rieko Osu(Waseda Univ.) |
| Vice Chair | Junichi Hori(Niigata Univ.) / Hiroshi Yamakawa(Univ of Tokyo) |
| Secretary | Junichi Hori(Osaka Electro-Communication Univ) / Hiroshi Yamakawa(ATR) |
| Assistant | Jun Akazawa(Meiji Univ. of Integrative Medicine) / Emi Yuda(Tohoku Univ) / Nobuhiko Wagatsuma(Toho Univ.) / Tomoki Kurikawa(KMU) |
| Paper Information | |
| Registration To | Technical Committee on ME and Bio Cybernetics / Technical Committee on Neurocomputing |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Computer simulations of colorectal tumor development |
| Sub Title (in English) | |
| Keyword(1) | Circadian ryhthm |
| Keyword(2) | Cell cycle |
| Keyword(3) | Intestinal cancer |
| Keyword(4) | Mathematical model |
| 1st Author's Name | Riku Ichinohe |
| 1st Author's Affiliation | Tohoku University(Tohoku Univ.) |
| 2nd Author's Name | Norihiro Katayama |
| 2nd Author's Affiliation | Tohoku University/Shokei Gakuin University(Tohoku Univ./Shokei Univ.) |
| 3rd Author's Name | Mitsuyuki Nakao |
| 3rd Author's Affiliation | Tohoku University(Tohoku Univ.) |
| Date | 2021-10-29 |
| Paper # | MBE2021-23 |
| Volume (vol) | vol.121 |
| Number (no) | MBE-222 |
| Page | pp.pp.32-36(MBE), |
| #Pages | 5 |
| Date of Issue | 2021-10-21 (MBE) |