| Presentation | 2021-03-03 A sensing system for drug side effects on hERG channels for personalized medicine. Takaya Watanabe, Ryo Yokota, Miki Kato, Madoka Sato, Daisuke Tadaki, Maki Komiya, Hideaki Yamamoto, Michio Niwano, Ayumi Hirano, |
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| PDF Download Page |  PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Ion channels regulate ion permeation through cell membranes, of which function is very important to control bioelectric signals in vivo. The hERG channel, a potassium channel in cardiomyocites, has been reported to be inhibited by drugs, which sometimes causes lethal arrhythmia. In this study, we focused on evaluation of drug side-effects on the hERG channels based on a reconstitution system in which the hERG channel was embedded in an artificial bilayer lipid membrane (BLM). |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Semiconductor microfabrication / Ion channel / Bilayer lipid membrane / Cell-free expression system / Drug side-effect |
| Paper # | CPM2020-72 |
| Date of Issue | 2021-02-24 (CPM) |
| Conference Information | |
| Committee | CPM |
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| Conference Date | 2021/3/3(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | Online |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
| Chair | Mayumi Takeyama(Kitami Inst. of Tech.) |
| Vice Chair | Yuichi Nakamura(Toyohashi Univ. of Tech.) |
| Secretary | Yuichi Nakamura(Hirosaki Univ.) |
| Assistant | Yasuo Kimura(Tokyo Univ. of Tech.) / Tomoaki Terasako(Ehime Univ.) / Fumihiko Hirose(Yamagata Univ.) |
| Paper Information | |
| Registration To | Technical Committee on Component Parts and Materials |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | A sensing system for drug side effects on hERG channels for personalized medicine. |
| Sub Title (in English) | |
| Keyword(1) | Semiconductor microfabrication |
| Keyword(2) | Ion channel |
| Keyword(3) | Bilayer lipid membrane |
| Keyword(4) | Cell-free expression system |
| Keyword(5) | Drug side-effect |
| 1st Author's Name | Takaya Watanabe |
| 1st Author's Affiliation | Tohoku University(Tohoku Univ) |
| 2nd Author's Name | Ryo Yokota |
| 2nd Author's Affiliation | Tohoku University(Tohoku Univ) |
| 3rd Author's Name | Miki Kato |
| 3rd Author's Affiliation | Tohoku University(Tohoku Univ) |
| 4th Author's Name | Madoka Sato |
| 4th Author's Affiliation | Tohoku University(Tohoku Univ) |
| 5th Author's Name | Daisuke Tadaki |
| 5th Author's Affiliation | Tohoku University(Tohoku Univ) |
| 6th Author's Name | Maki Komiya |
| 6th Author's Affiliation | Tohoku University(Tohoku Univ) |
| 7th Author's Name | Hideaki Yamamoto |
| 7th Author's Affiliation | Tohoku University(Tohoku Univ) |
| 8th Author's Name | Michio Niwano |
| 8th Author's Affiliation | Tohoku Fukushi Universiyu(Tohoku Fukushi Univ) |
| 9th Author's Name | Ayumi Hirano |
| 9th Author's Affiliation | Tohoku University(Tohoku Univ) |
| Date | 2021-03-03 |
| Paper # | CPM2020-72 |
| Volume (vol) | vol.120 |
| Number (no) | CPM-408 |
| Page | pp.pp.62-63(CPM), |
| #Pages | 2 |
| Date of Issue | 2021-02-24 (CPM) |