| Presentation | 2021-01-21 Modulation of the electrical activity of pancreatic alpha cells by their intrinsic mechanisms and by paracrine effects from pancreatic beta cells Yuto Nishide, Shinji Doi, |
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| PDF Download Page |  PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | The $alpha$-cells in the pancreatic islets are electrically excitable and secrete glucagon in response to low blood glucose levels. The mechanism by which glucose regulates the glucagon secretion is not clear in detail. On the one hand, ATP-sensitive $rm K^{+}$ channels and store-operated currents are considered as one of the regulation mechanisms (intrinsic mechanisms). On the other hand, it is reported that factors released from other cells within islet also regulate secretion of glucagon. In this study, we used the mathematical model for $alpha$-cells which takes into account electrical activity, $rm Ca^{2+}$-dynamics, and the influence of ATP-sensitive $rm K^{+}$ channels, store-operated currents and insulin released from $beta$-cells. Then we investigate how these mechanisms regulate the glucagon-secretion in $alpha$-cell responding to the blood glucose levels. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | pancreatic $¥alpha$-cell / ATP-sensitive $rm K^{+}$ channels / store operated currents / paracrine effects |
| Paper # | NLP2020-47 |
| Date of Issue | 2021-01-14 (NLP) |
| Conference Information | |
| Committee | NC / NLP |
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| Conference Date | 2021/1/21(2days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | Online |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | NC，NLP |
| Chair | Kazuyuki Samejima(Tamagawa Univ) / Kiyohisa Natsume(Kyushu Inst. of Tech.) |
| Vice Chair | Rieko Osu(Waseda Univ.) / Takuji Kosaka(Chukyo Univ.) |
| Secretary | Rieko Osu(NTT) / Takuji Kosaka(ATR) |
| Assistant | Ken Takiyama(TUAT) / Nobuhiko Wagatsuma(Toho Univ.) / Toshikaza Samura(Yamaguchi Univ.) / Hideyuki Kato(Oita Univ.) |
| Paper Information | |
| Registration To | Technical Committee on Neurocomputing / Technical Committee on Nonlinear Problems |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Modulation of the electrical activity of pancreatic alpha cells by their intrinsic mechanisms and by paracrine effects from pancreatic beta cells |
| Sub Title (in English) | |
| Keyword(1) | pancreatic $¥alpha$-cell |
| Keyword(2) | ATP-sensitive $rm K^{+}$ channels |
| Keyword(3) | store operated currents |
| Keyword(4) | paracrine effects |
| 1st Author's Name | Yuto Nishide |
| 1st Author's Affiliation | Kyoto University(Kyoto Univ.) |
| 2nd Author's Name | Shinji Doi |
| 2nd Author's Affiliation | Kyoto University(Kyoto Univ.) |
| Date | 2021-01-21 |
| Paper # | NLP2020-47 |
| Volume (vol) | vol.120 |
| Number (no) | NLP-330 |
| Page | pp.pp.36-41(NLP), |
| #Pages | 6 |
| Date of Issue | 2021-01-14 (NLP) |