| Presentation | 2020-10-29 Analysis of the drift-diffusion properties in the mouse brain parenchyma by the functional integrative optical imaging method Akihisa Takahashi, Kenya Tanaka, Mitsuyuki Nakao, Norihiro Katayama, |
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| PDF Download Page |  PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Recently, it has been found that the vertebrate brain has a unique waste clearance pathway called the glymphatic system. One of the unsolved problems of the system is whether the cerebrospinal fluid (CSF) flows in a constant direction or not in the brain parenchyma. To address this issue, we analyzed the diffusion property of the brain by the functional integrative optical imaging (fIOI) method. We measured the diffusion of fluorescent molecules injected in the brain parenchyma and analyzed time-lapse images of the fluoresce. It was found that the diffusion drifted toward a constant direction. The result supports the existence of the constant flow of the CSF in the brain parenchyma. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Glymphatic System / extracellular space (ECS) / Cerebrospinal fluid (CSF) |
| Paper # | MBE2020-17 |
| Date of Issue | 2020-10-22 (MBE) |
| Conference Information | |
| Committee | MBE / NC / NLP / CAS |
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| Conference Date | 2020/10/29(2days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | Online |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | ME，NC，CAS，NLP |
| Chair | Takashi Watanabe(Tohoku Univ.) / Kazuyuki Samejima(Tamagawa Univ) / Kiyohisa Natsume(Kyushu Inst. of Tech.) / Yasuhiro Takashima(Univ. of Kitakyushu) |
| Vice Chair | Ryuhei Okuno(Setsunan Univ.) / Rieko Osu(Waseda Univ.) / Takuji Kosaka(Chukyo Univ.) / Hiroki Sato(Sony LSI Design) |
| Secretary | Ryuhei Okuno(Akita-noken) / Rieko Osu(NTT) / Takuji Kosaka(ATR) / Hiroki Sato(Kyushu Inst. of Tech.) |
| Assistant | Akihiro Karashima(Tohoku Inst. of Tech.) / Jun Akazawa(Meiji Univ. of Integrative Medicine) / Ken Takiyama(TUAT) / Nobuhiko Wagatsuma(Toho Univ.) / Toshikaza Samura(Yamaguchi Univ.) / Hideyuki Kato(Oita Univ.) / Motoi Yamaguchi(TECHNOPRO) / Yohei Nakamura(Hitachi) |
| Paper Information | |
| Registration To | Technical Committee on ME and Bio Cybernetics / Technical Committee on Neurocomputing / Technical Committee on Nonlinear Problems / Technical Committee on Circuits and Systems |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Analysis of the drift-diffusion properties in the mouse brain parenchyma by the functional integrative optical imaging method |
| Sub Title (in English) | |
| Keyword(1) | Glymphatic System |
| Keyword(2) | extracellular space (ECS) |
| Keyword(3) | Cerebrospinal fluid (CSF) |
| 1st Author's Name | Akihisa Takahashi |
| 1st Author's Affiliation | Tohoku University(Tohoku Univ) |
| 2nd Author's Name | Kenya Tanaka |
| 2nd Author's Affiliation | Tohoku University(Tohoku Univ) |
| 3rd Author's Name | Mitsuyuki Nakao |
| 3rd Author's Affiliation | Tohoku University(Tohoku Univ) |
| 4th Author's Name | Norihiro Katayama |
| 4th Author's Affiliation | Tohoku University(Tohoku Univ) |
| Date | 2020-10-29 |
| Paper # | MBE2020-17 |
| Volume (vol) | vol.120 |
| Number (no) | MBE-215 |
| Page | pp.pp.23-26(MBE), |
| #Pages | 4 |
| Date of Issue | 2020-10-22 (MBE) |