| Presentation | 2020-06-05 The electroencephalography and the effect of acetylcholine for it in hippocampal slices of the epileptic animals model. Hirofumi Arai, Blanco Negrete Salvador, Rollyn Labuguen, Tomohiro Shibata, Kiyohisa Natsume, |
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| PDF Download Page |  PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Once a balance between excitation and inhibition in a brain is disrupted, mental disorder will occur. One of the disorders is the temporal lobe epilepsy. Fifteen percent of the epileptic patients cannot get over with the medicine. θ rhythm suppresses the epileptic discharges. In the previous study we found that β rhythm also will suppress the generation of the discharges, and propose the stimulation with β frequency is a therapy for the epileptic patients. However, it is not yet found whether the suppression of the epileptic discharges by β rhythm occurs in vivo. We made kainate-induced epileptic model of rat, and have been studying the effect of β rhythm on the epileptic discharges. In the present study, we study the hippocampal neuronal network in the rat model. The rats in kainate (KA) group had the significantly more frequent Grooming behavior a week after KA injection than those in Control group. The rate of spontaneous activity was higher in hippocampal slices in KA group than in Control one. The slices in KA group also had the spontaneous activities with longer duration. There were the spontaneous activities observed in KA slices and not seen in the Control slices. When a cholinergic agent carbachol was applied to the slices, the activities were diminished in both groups, and carbachol-induced β oscillations (CIBO) were induced. The frequencies of CIBO in KA were significantly higher than those in Control. In addition, the application of carbachol with picrotoxin GABAA receptor antagonist decreased CIBO frequency, which was about the same as that in Control. These results suggest that the inhibitory neurons are more activated in hippocampus in KA group, β wave will suppress the spontaneous activities related to the epileptic discharges. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Epilepsy treatment / kainic acid / vivo model / Bata oscillation / Hippocampus / GABA receptor |
| Paper # | NLP2020-18,CCS2020-8 |
| Date of Issue | 2020-05-29 (NLP, CCS) |
| Conference Information | |
| Committee | CCS / NLP |
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| Conference Date | 2020/6/5(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | Shonan Institute of Technology |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
| Chair | Shigeki Shiokawa(Kanagawa Inst. of Tech.) / Kiyohisa Natsume(Kyushu Inst. of Tech.) |
| Vice Chair | Tetsuya Asai(Hokkaido Univ.) / Megumi Akai(Hokkaido Univ.) / Takuji Kosaka(Chukyo Univ.) |
| Secretary | Tetsuya Asai(Kanagawa Inst. of Tech.) / Megumi Akai(TDK) / Takuji Kosaka(Kyushu Inst. of Tech.) |
| Assistant | Hidehiro Nakano(Tokyo City Univ.) / Hiroyasu Ando(Tsukuba Univ.) / Takashi Matsubara(Kobe Univ.) / Kosuke Sanada(Mie Univ.) / Toshikaza Samura(Yamaguchi Univ.) / Hideyuki Kato(Oita Univ.) |
| Paper Information | |
| Registration To | Technical Committee on Complex Communication Sciences / Technical Committee on Nonlinear Problems |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | The electroencephalography and the effect of acetylcholine for it in hippocampal slices of the epileptic animals model. |
| Sub Title (in English) | |
| Keyword(1) | Epilepsy treatment |
| Keyword(2) | kainic acid |
| Keyword(3) | vivo model |
| Keyword(4) | Bata oscillation |
| Keyword(5) | Hippocampus |
| Keyword(6) | GABA receptor |
| 1st Author's Name | Hirofumi Arai |
| 1st Author's Affiliation | Kyusyu Institute of Technology(Kyutech) |
| 2nd Author's Name | Blanco Negrete Salvador |
| 2nd Author's Affiliation | Kyusyu Institute of Technology(Kyutech) |
| 3rd Author's Name | Rollyn Labuguen |
| 3rd Author's Affiliation | Kyusyu Institute of Technology(Kyutech) |
| 4th Author's Name | Tomohiro Shibata |
| 4th Author's Affiliation | Kyusyu Institute of Technology(Kyutech) |
| 5th Author's Name | Kiyohisa Natsume |
| 5th Author's Affiliation | Kyusyu Institute of Technology(Kyutech) |
| Date | 2020-06-05 |
| Paper # | NLP2020-18,CCS2020-8 |
| Volume (vol) | vol.120 |
| Number (no) | NLP-55,CCS-56 |
| Page | pp.pp.35-40(NLP), pp.35-40(CCS), |
| #Pages | 6 |
| Date of Issue | 2020-05-29 (NLP, CCS) |