| Presentation | 2020-01-30 Evaluation of nerve response in a mouse model by temporal interference stimulation Akihiro Asai, Gomez-Tames Jose, Akimasa Hirata, |
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| PDF Download Page |  PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | In recent years, there has been a growing interest in stimulating deeper brain tissue non-invasively while reducing unintended stimulation in superficial regions for medical treatment of brain disorders. The traditional methods for noninvasive brain stimulation (transcranial direct current stimulation or transcranial magnetic stimulation) can target deeper brain regions but with the cost of stimulating at the same time superficial regions. Recently, temporal interference (TI) stimulation has been proposed to enable stimulation of deeper brain regions selectively. TI generates a modulated envelope by superposing two slightly different alternating currents within the kHz range (carrier frequencies) that are injected through attached electrodes to the scalp. Previous studies have reported promising results in experiments using mice, but it has not yet been clarified the mechanism of activation. In this paper, we investigated the mechanism of activation by using a multiscale model that computes the generated interference current patters effects in a neural model. As a result, the threshold increased with the carrier frequency as the experimental study. It was also found that changing the intensity ratio between the alternating currents moved the location of the responding nerve in agreement with the experiments. We found that particular characteristics of the envelope may facilitate the interferential effects. The computational results showed that for a neuron driven by an interferential envelope with valley value close to zero was more determinant than peak-to-valley magnitude to estimate activation. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | tACS / transcranial Temporal Interference Stimulation / Mouse Model / Deep Brain Region / SPFD / Nerve Model |
| Paper # | EST2019-88 |
| Date of Issue | 2020-01-23 (EST) |
| Conference Information | |
| Committee | EST |
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| Conference Date | 2020/1/30(2days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | Beppu International Convention Center |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | Simulation Technique, etc. |
| Chair | Akimasa Hirata(Nagoya Inst. of Tech.) |
| Vice Chair | Shinichiro Ohnuki(Nihon Univ.) / Masayuki Kimishima(Advantest) / Jun Shibayama(Hosei Univ.) |
| Secretary | Shinichiro Ohnuki(National Inst. of Tech.,Sendai College) / Masayuki Kimishima(Aoyama Gakuin Univ.) / Jun Shibayama |
| Assistant | Takahiro Ito(Nagoya Inst. of Tech.) / Kazuhiro Fujita(Fujitsu) |
| Paper Information | |
| Registration To | Technical Committee on Electronics Simulation Technology |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Evaluation of nerve response in a mouse model by temporal interference stimulation |
| Sub Title (in English) | |
| Keyword(1) | tACS |
| Keyword(2) | transcranial Temporal Interference Stimulation |
| Keyword(3) | Mouse Model |
| Keyword(4) | Deep Brain Region |
| Keyword(5) | SPFD |
| Keyword(6) | Nerve Model |
| 1st Author's Name | Akihiro Asai |
| 1st Author's Affiliation | Nagoya Institue of Technology(NITech) |
| 2nd Author's Name | Gomez-Tames Jose |
| 2nd Author's Affiliation | Nagoya Institue of Technology(NITech) |
| 3rd Author's Name | Akimasa Hirata |
| 3rd Author's Affiliation | Nagoya Institue of Technology(NITech) |
| Date | 2020-01-30 |
| Paper # | EST2019-88 |
| Volume (vol) | vol.119 |
| Number (no) | EST-407 |
| Page | pp.pp.51-56(EST), |
| #Pages | 6 |
| Date of Issue | 2020-01-23 (EST) |