| Presentation | 2019-03-01 Quantitative assessment of drug side effect on hERG channels based on artificial bilayer lipid membranes and cell-free expression system Ryo yokota, Miki Kato, Daichi Yamaura, Yusuke Tsuneta, Madoka Sato, Daisuke Tadaki, Maki Komiya, Hideaki Yamamoto, Haruka Inoue, Yuzuru Tozawa, Michio Niwano, Ayumi Hirano-Iwata, |
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| PDF Download Page |  PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | We aim to develop a drug screening system based on a reconstitution system, in which an ion channel is embedded in an artificial bilayer lipid membrane. We have reported the formation of a stable lipid bilayer membrane (BLM) based on silicon (Si) microfabrication and the method for promotion of embedding ion channels in the membranes. Here, we applied the BLM system to quantitative assessment of drug side effects on cell-free synthesized hERG channel proteins. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Semiconductor microfabrication / Ion channel / Lipid bilayer membrane / Cell-free expression system / Drug side effect |
| Paper # | CPM2018-119 |
| Date of Issue | 2019-02-21 (CPM) |
| Conference Information | |
| Committee | CPM |
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| Conference Date | 2019/2/28(2days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | Young Researcher's Conference |
| Chair | Fumihiko Hirose(Yamagata Univ.) |
| Vice Chair | Mayumi Takeyama(Kitami Inst. of Tech.) |
| Secretary | Mayumi Takeyama(Toyohashi Univ. of Tech.) |
| Assistant | Yasuo Kimura(Tokyo Univ. of Tech.) / Hideki Nakazawa(Hirosaki Univ.) / Tomoaki Terasako(Ehime Univ.) |
| Paper Information | |
| Registration To | Technical Committee on Component Parts and Materials |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Quantitative assessment of drug side effect on hERG channels based on artificial bilayer lipid membranes and cell-free expression system |
| Sub Title (in English) | |
| Keyword(1) | Semiconductor microfabrication |
| Keyword(2) | Ion channel |
| Keyword(3) | Lipid bilayer membrane |
| Keyword(4) | Cell-free expression system |
| Keyword(5) | Drug side effect |
| 1st Author's Name | Ryo yokota |
| 1st Author's Affiliation | Tohoku University(Tohoku Univ.) |
| 2nd Author's Name | Miki Kato |
| 2nd Author's Affiliation | Tohoku University(Tohoku Univ.) |
| 3rd Author's Name | Daichi Yamaura |
| 3rd Author's Affiliation | Tohoku University(Tohoku Univ.) |
| 4th Author's Name | Yusuke Tsuneta |
| 4th Author's Affiliation | Tohoku University(Tohoku Univ.) |
| 5th Author's Name | Madoka Sato |
| 5th Author's Affiliation | Tohoku University(Tohoku Univ.) |
| 6th Author's Name | Daisuke Tadaki |
| 6th Author's Affiliation | Tohoku University(Tohoku Univ.) |
| 7th Author's Name | Maki Komiya |
| 7th Author's Affiliation | Tohoku University(Tohoku Univ.) |
| 8th Author's Name | Hideaki Yamamoto |
| 8th Author's Affiliation | Tohoku University(Tohoku Univ.) |
| 9th Author's Name | Haruka Inoue |
| 9th Author's Affiliation | Saitama University(Saitama Univ.) |
| 10th Author's Name | Yuzuru Tozawa |
| 10th Author's Affiliation | Saitama University(Saitama Univ.) |
| 11th Author's Name | Michio Niwano |
| 11th Author's Affiliation | Tohoku Fukushi University(Tohoku Fukushi Univ.) |
| 12th Author's Name | Ayumi Hirano-Iwata |
| 12th Author's Affiliation | Tohoku University(Tohoku Univ.) |
| Date | 2019-03-01 |
| Paper # | CPM2018-119 |
| Volume (vol) | vol.118 |
| Number (no) | CPM-461 |
| Page | pp.pp.75-76(CPM), |
| #Pages | 2 |
| Date of Issue | 2019-02-21 (CPM) |