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| Presentation | 2022-06-17 15:25 Studies on ultrasonically and microbubble-induced blood-brain barrier opening using a gel capillary phantom Miryu Shinzato, Kato Yuji, Hashimoto Mamoru, Nobuki Kudo (Hokkaido Univ.)  MBE2022-10 |
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| Abstract | (in Japanese) | (See Japanese page) |
| (in English) | DOX-Alb is albumin nanoparticles of approximately 160 nm in diameter with anticancer drug doxorubicin (DOX) adhering to their surfaces. DOX-Alb is used to deliver the drug to tumor tissue by intravascular injection of DOX-Alb with microbubbles and sonication. This study developed a capillary phantom with a 10 µm diameter lumen using acrylamide gel to validate the basic idea method. An experiment to introduce DOX or DOX-Alb into the lumen confirmed that the phantom has the characteristics of diffusing low molecular weight DOX and retaining DOX-Alb nanoparticles inside the lumen, as in biological capillaries. Another experiment to irradiate the phantom by one-shot ultrasound burst pulse (1 MHz, 1 MPa in negative peat pressure, and 50 or 1,000 cycles) showed that bubble oscillation enhances DOX diffusion and induces lumen deformation and leakage of DOX-Alb. This phantom is expected to play an essential role in understanding the phenomena occurring in capillaries. | |
| Keyword | (in Japanese) | (See Japanese page) |
| (in English) | Ultrasound / microbubbles / drug delivery / capillary / gel phantom / nano particles / / | |
| Reference Info. | IEICE Tech. Rep., vol. 122, no. 82, MBE2022-10, pp. 12-12, June 2022. | |
| Paper # | MBE2022-10 | |
| Date of Issue | 2022-06-10 (MBE) | |
| ISSN | Online edition: ISSN 2432-6380 | |
| Copyright and reproduction |
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034) | |
| Download PDF | MBE2022-10 |
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| Conference Information | |
| Committee | MBE IEE-MBE |
| Conference Date | 2022-06-17 - 2022-06-17 |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | Online |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | ME, etc. |
| Paper Information | |
| Registration To | MBE |
| Conference Code | 2022-06-MBE-MBE |
| Language | Japanese |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Studies on ultrasonically and microbubble-induced blood-brain barrier opening using a gel capillary phantom |
| Sub Title (in English) | |
| Keyword(1) | Ultrasound |
| Keyword(2) | microbubbles |
| Keyword(3) | drug delivery |
| Keyword(4) | capillary |
| Keyword(5) | gel phantom |
| Keyword(6) | nano particles |
| Keyword(7) | |
| Keyword(8) | |
| 1st Author's Name | Miryu Shinzato |
| 1st Author's Affiliation | Hokkaido University (Hokkaido Univ.) |
| 2nd Author's Name | Kato Yuji |
| 2nd Author's Affiliation | Hokkaido University (Hokkaido Univ.) |
| 3rd Author's Name | Hashimoto Mamoru |
| 3rd Author's Affiliation | Hokkaido University (Hokkaido Univ.) |
| 4th Author's Name | Nobuki Kudo |
| 4th Author's Affiliation | Hokkaido University (Hokkaido Univ.) |
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| Speaker | Author-4 |
| Date Time | 2022-06-17 15:25:00 |
| Presentation Time | 25 minutes |
| Registration for | MBE |
| Paper # | MBE2022-10 |
| Volume (vol) | vol.122 |
| Number (no) | no.82 |
| Page | p.12 |
| #Pages | 1 |
| Date of Issue | 2022-06-10 (MBE) |
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