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Paper Abstract and Keywords
Presentation 2021-12-22 13:30
[Poster Presentation] Relationship between the vibration of a bubble and the amount of adsorbed molecules desorbed by ultrasonic irradiation
Reina Kobayashi, Natsumi Nakaoka, Hiraku Tabata, Daisuke Koyama (Doshisha Univ.), Marie Pierre Krafft (Strasbourg Univ.) US2021-51
Abstract (in Japanese) (See Japanese page) 
(in English) Microbubbles have potential for applications as drug and gene carriers, and the drug release can be triggered by ultrasound irradiation in blood vessels. In this paper, the molecular desorption from a single microbubble under ultrasound irradiation was observed, and the amount of molecules desorbed from the bubble surface was estimated quantitatively. Microbubbles with a lipid shell and a radius of 20 to 440 μm were fabricated. DMPC and poorly-soluble gas were used as the shell material and internal gas, respectively. The optical observation system consisted of a high-speed camera with a long-distance microscope and an ultrasound observational cell. The amount of the molecules desorbed from a single microbubble was estimated from the contact angle between the bubble and a glass plate installed in the observational cell. The vibration of a single bubble in the radial direction was measured using a laser Doppler vibrometer. In the case of the driving frequency of 38.8 kHz, the resonance radius of the microbubbles was 99 m where the vibrational amplitude was maximized. From the relationship between the vibrational characteristics and the amount of molecular desorption, it was found that a larger vibrational amplitude of the bubble around the resonance size induces a larger amount of the molecular desorption.
Keyword (in Japanese) (See Japanese page) 
(in English) microbubble / drug delivery system / phospholipid / desorption / / / /  
Reference Info. IEICE Tech. Rep., vol. 121, no. 310, US2021-51, pp. 22-25, Dec. 2021.
Paper # US2021-51 
Date of Issue 2021-12-15 (US) 
ISSN Online edition: ISSN 2432-6380
Copyright
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All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
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Conference Information
Committee EA US  
Conference Date 2021-12-22 - 2021-12-23 
Place (in Japanese) (See Japanese page) 
Place (in English) Sojo University 
Topics (in Japanese) (See Japanese page) 
Topics (in English) [Joint Meeting on Acoustics and Ultrasonics Subsociety] Engineering/Electro Acoustics, Ultrasonics, etc. 
Paper Information
Registration To US 
Conference Code 2021-12-EA-US 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Relationship between the vibration of a bubble and the amount of adsorbed molecules desorbed by ultrasonic irradiation 
Sub Title (in English)  
Keyword(1) microbubble  
Keyword(2) drug delivery system  
Keyword(3) phospholipid  
Keyword(4) desorption  
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1st Author's Name Reina Kobayashi  
1st Author's Affiliation Doshisha University (Doshisha Univ.)
2nd Author's Name Natsumi Nakaoka  
2nd Author's Affiliation Doshisha University (Doshisha Univ.)
3rd Author's Name Hiraku Tabata  
3rd Author's Affiliation Doshisha University (Doshisha Univ.)
4th Author's Name Daisuke Koyama  
4th Author's Affiliation Doshisha University (Doshisha Univ.)
5th Author's Name Marie Pierre Krafft  
5th Author's Affiliation University of Strasbourg (Strasbourg Univ.)
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Speaker Author-1 
Date Time 2021-12-22 13:30:00 
Presentation Time 120 minutes 
Registration for US 
Paper # US2021-51 
Volume (vol) vol.121 
Number (no) no.310 
Page pp.22-25 
#Pages
Date of Issue 2021-12-15 (US) 


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