Paper Abstract and Keywords |
Presentation |
2021-11-19 13:25
Energy efficient control of bursts' rhythm in a mathematical model of the pancreatic beta cell Keita Koyama (Univ. of Tsukuba), Hiroyasu Ando (Tohoku Univ./Univ. of Tsukuba), Kantaro Fujiwara (Univ. of Tokyo) CCS2021-31 |
Abstract |
(in Japanese) |
(See Japanese page) |
(in English) |
Bursting activity of pancreatic beta cells are correlated with the function of insulin secretion. While normal pancreatic $beta$-cells show periodic bursting, the bursting activity becomes irregular in dysfunctional pancreatic $beta$-cells of type 2 diabetic patients. In this study, we reproduced the dynamics of dysfunctional pancreatic $beta$-cells using a mathematical model and investigated it in terms of the energy efficient control of burst's rhythm. The control method is considered for on-demand electrical stimulation in terms of the methodology of chaos control. As a result of numerical simulations, the bursts are controlled in periodic rhythm by a feedback input. In addition, we have found input timings that induce energy efficient control of bursts' rhythm. These results suggest that chaos control may improve the function of insulin secretion, which may contribute to the treatment of type 2 diabetes. |
Keyword |
(in Japanese) |
(See Japanese page) |
(in English) |
Pancreatic beta-cell / Mathematical model / Dysfunction / On-demand / Energy efficient / Control of chaos / / |
Reference Info. |
IEICE Tech. Rep., vol. 121, no. 253, CCS2021-31, pp. 79-83, Nov. 2021. |
Paper # |
CCS2021-31 |
Date of Issue |
2021-11-11 (CCS) |
ISSN |
Online edition: ISSN 2432-6380 |
Copyright and reproduction |
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034) |
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CCS2021-31 |
Conference Information |
Committee |
CCS |
Conference Date |
2021-11-18 - 2021-11-19 |
Place (in Japanese) |
(See Japanese page) |
Place (in English) |
Osaka Univ. |
Topics (in Japanese) |
(See Japanese page) |
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Paper Information |
Registration To |
CCS |
Conference Code |
2021-11-CCS |
Language |
Japanese |
Title (in Japanese) |
(See Japanese page) |
Sub Title (in Japanese) |
(See Japanese page) |
Title (in English) |
Energy efficient control of bursts' rhythm in a mathematical model of the pancreatic beta cell |
Sub Title (in English) |
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Keyword(1) |
Pancreatic beta-cell |
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Mathematical model |
Keyword(3) |
Dysfunction |
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On-demand |
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Energy efficient |
Keyword(6) |
Control of chaos |
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1st Author's Name |
Keita Koyama |
1st Author's Affiliation |
University of Tsukuba (Univ. of Tsukuba) |
2nd Author's Name |
Hiroyasu Ando |
2nd Author's Affiliation |
Tohoku University/University of Tsukuba (Tohoku Univ./Univ. of Tsukuba) |
3rd Author's Name |
Kantaro Fujiwara |
3rd Author's Affiliation |
University of Tokyo (Univ. of Tokyo) |
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Speaker |
Author-1 |
Date Time |
2021-11-19 13:25:00 |
Presentation Time |
25 minutes |
Registration for |
CCS |
Paper # |
CCS2021-31 |
Volume (vol) |
vol.121 |
Number (no) |
no.253 |
Page |
pp.79-83 |
#Pages |
5 |
Date of Issue |
2021-11-11 (CCS) |
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