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| Presentation | 2021-03-03 14:40 A sensing system for drug side effects on hERG channels for personalized medicine. Takaya Watanabe, Ryo Yokota, Miki Kato, Madoka Sato, Daisuke Tadaki, Maki Komiya, Hideaki Yamamoto (Tohoku Univ), Michio Niwano (Tohoku Fukushi Univ), Ayumi Hirano (Tohoku Univ)  CPM2020-72 Link to ES Tech. Rep. Archives: CPM2020-72 |
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| Abstract | (in Japanese) | (See Japanese page) |
| (in English) | Ion channels regulate ion permeation through cell membranes, of which function is very important to control bioelectric signals in vivo. The hERG channel, a potassium channel in cardiomyocites, has been reported to be inhibited by drugs, which sometimes causes lethal arrhythmia. In this study, we focused on evaluation of drug side-effects on the hERG channels based on a reconstitution system in which the hERG channel was embedded in an artificial bilayer lipid membrane (BLM). | |
| Keyword | (in Japanese) | (See Japanese page) |
| (in English) | Semiconductor microfabrication / Ion channel / Bilayer lipid membrane / Cell-free expression system / Drug side-effect / / / | |
| Reference Info. | IEICE Tech. Rep., vol. 120, no. 408, CPM2020-72, pp. 62-63, March 2021. | |
| Paper # | CPM2020-72 | |
| Date of Issue | 2021-02-24 (CPM) | |
| ISSN | Online edition: ISSN 2432-6380 | |
| Copyright and reproduction |
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034) | |
| Download PDF | CPM2020-72 Link to ES Tech. Rep. Archives: CPM2020-72 |
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| Conference Information | |
| Committee | CPM |
| Conference Date | 2021-03-03 - 2021-03-03 |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | Online |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
| Paper Information | |
| Registration To | CPM |
| Conference Code | 2021-03-CPM |
| Language | Japanese |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | A sensing system for drug side effects on hERG channels for personalized medicine. |
| Sub Title (in English) | |
| Keyword(1) | Semiconductor microfabrication |
| Keyword(2) | Ion channel |
| Keyword(3) | Bilayer lipid membrane |
| Keyword(4) | Cell-free expression system |
| Keyword(5) | Drug side-effect |
| Keyword(6) | |
| Keyword(7) | |
| Keyword(8) | |
| 1st Author's Name | Takaya Watanabe |
| 1st Author's Affiliation | Tohoku University (Tohoku Univ) |
| 2nd Author's Name | Ryo Yokota |
| 2nd Author's Affiliation | Tohoku University (Tohoku Univ) |
| 3rd Author's Name | Miki Kato |
| 3rd Author's Affiliation | Tohoku University (Tohoku Univ) |
| 4th Author's Name | Madoka Sato |
| 4th Author's Affiliation | Tohoku University (Tohoku Univ) |
| 5th Author's Name | Daisuke Tadaki |
| 5th Author's Affiliation | Tohoku University (Tohoku Univ) |
| 6th Author's Name | Maki Komiya |
| 6th Author's Affiliation | Tohoku University (Tohoku Univ) |
| 7th Author's Name | Hideaki Yamamoto |
| 7th Author's Affiliation | Tohoku University (Tohoku Univ) |
| 8th Author's Name | Michio Niwano |
| 8th Author's Affiliation | Tohoku Fukushi Universiyu (Tohoku Fukushi Univ) |
| 9th Author's Name | Ayumi Hirano |
| 9th Author's Affiliation | Tohoku University (Tohoku Univ) |
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| Speaker | Author-1 |
| Date Time | 2021-03-03 14:40:00 |
| Presentation Time | 15 minutes |
| Registration for | CPM |
| Paper # | CPM2020-72 |
| Volume (vol) | vol.120 |
| Number (no) | no.408 |
| Page | pp.62-63 |
| #Pages | 2 |
| Date of Issue | 2021-02-24 (CPM) |
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