Paper Abstract and Keywords |
Presentation |
2020-03-09 10:50
Analysis of a pancreatic beta cell model including glycolysis system based on slow-fast decomposition and bifurcation analysis
-- Focusing on the effects of external input and blood glucose -- Tomoki Sugiura, Shinji Doi (Kyoto Univ.) NLP2019-117 |
Abstract |
(in Japanese) |
(See Japanese page) |
(in English) |
Insulin secreted by $beta$ cells in pancreatic islets is involved in blood glucose regulation, and insulin secretion is closely related to their electrical activity (action potential).
The action potential shows a characteristic waveform called bursting.
Bursting has been analyzed using mathematical models, and has been shown to be related to various bifurcation phenomena.
Recently, It is considered that not only $beta$ cells but also other cells in pancreatic islets play an important role in regulating blood glucose levels.
In this study, in order to reveal the mechanism of blood glucose regulation by the interactions between various cells of the pancreatic islets, we analyze $beta$ cells focusing on input (external input current and blood glucose) and output (bursting).
We investigate how blood glucose level and external input affect $beta$ cells using a mathematical model of $beta$ cells including glycolysis system based on bifurcation analysis and fast-slow decomposition of vector fields. |
Keyword |
(in Japanese) |
(See Japanese page) |
(in English) |
Bursting / Pancreatic beta cell / Glycolysis system / Bifurcation analysis / Slow-fast decomposition / / / |
Reference Info. |
IEICE Tech. Rep., vol. 119, no. 471, NLP2019-117, pp. 25-30, March 2020. |
Paper # |
NLP2019-117 |
Date of Issue |
2020-03-02 (NLP) |
ISSN |
Print edition: ISSN 0913-5685 Online edition: ISSN 2432-6380 |
Copyright and reproduction |
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034) |
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NLP2019-117 |
Conference Information |
Committee |
MSS NLP |
Conference Date |
2020-03-09 - 2020-03-10 |
Place (in Japanese) |
(See Japanese page) |
Place (in English) |
|
Topics (in Japanese) |
(See Japanese page) |
Topics (in English) |
SICE-DES, IEICE-MSS, IEICE-NLP |
Paper Information |
Registration To |
NLP |
Conference Code |
2020-03-MSS-NLP |
Language |
Japanese |
Title (in Japanese) |
(See Japanese page) |
Sub Title (in Japanese) |
(See Japanese page) |
Title (in English) |
Analysis of a pancreatic beta cell model including glycolysis system based on slow-fast decomposition and bifurcation analysis |
Sub Title (in English) |
Focusing on the effects of external input and blood glucose |
Keyword(1) |
Bursting |
Keyword(2) |
Pancreatic beta cell |
Keyword(3) |
Glycolysis system |
Keyword(4) |
Bifurcation analysis |
Keyword(5) |
Slow-fast decomposition |
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1st Author's Name |
Tomoki Sugiura |
1st Author's Affiliation |
Kyoto University (Kyoto Univ.) |
2nd Author's Name |
Shinji Doi |
2nd Author's Affiliation |
Kyoto University (Kyoto Univ.) |
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Speaker |
Author-1 |
Date Time |
2020-03-09 10:50:00 |
Presentation Time |
25 minutes |
Registration for |
NLP |
Paper # |
NLP2019-117 |
Volume (vol) |
vol.119 |
Number (no) |
no.471 |
Page |
pp.25-30 |
#Pages |
6 |
Date of Issue |
2020-03-02 (NLP) |
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