Paper Abstract and Keywords |
Presentation |
2020-01-30 15:15
Evaluation of nerve response in a mouse model by temporal interference stimulation Akihiro Asai, Gomez-Tames Jose, Akimasa Hirata (NITech) EST2019-88 Link to ES Tech. Rep. Archives: EST2019-88 |
Abstract |
(in Japanese) |
(See Japanese page) |
(in English) |
In recent years, there has been a growing interest in stimulating deeper brain tissue non-invasively while reducing unintended stimulation in superficial regions for medical treatment of brain disorders. The traditional methods for noninvasive brain stimulation (transcranial direct current stimulation or transcranial magnetic stimulation) can target deeper brain regions but with the cost of stimulating at the same time superficial regions. Recently, temporal interference (TI) stimulation has been proposed to enable stimulation of deeper brain regions selectively. TI generates a modulated envelope by superposing two slightly different alternating currents within the kHz range (carrier frequencies) that are injected through attached electrodes to the scalp. Previous studies have reported promising results in experiments using mice, but it has not yet been clarified the mechanism of activation. In this paper, we investigated the mechanism of activation by using a multiscale model that computes the generated interference current patters effects in a neural model. As a result, the threshold increased with the carrier frequency as the experimental study. It was also found that changing the intensity ratio between the alternating currents moved the location of the responding nerve in agreement with the experiments. We found that particular characteristics of the envelope may facilitate the interferential effects. The computational results showed that for a neuron driven by an interferential envelope with valley value close to zero was more determinant than peak-to-valley magnitude to estimate activation. |
Keyword |
(in Japanese) |
(See Japanese page) |
(in English) |
tACS / transcranial Temporal Interference Stimulation / Mouse Model / Deep Brain Region / SPFD / Nerve Model / / |
Reference Info. |
IEICE Tech. Rep., vol. 119, no. 407, EST2019-88, pp. 51-56, Jan. 2020. |
Paper # |
EST2019-88 |
Date of Issue |
2020-01-23 (EST) |
ISSN |
Print edition: ISSN 0913-5685 Online edition: ISSN 2432-6380 |
Copyright and reproduction |
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034) |
Download PDF |
EST2019-88 Link to ES Tech. Rep. Archives: EST2019-88 |
Conference Information |
Committee |
EST |
Conference Date |
2020-01-30 - 2020-01-31 |
Place (in Japanese) |
(See Japanese page) |
Place (in English) |
Beppu International Convention Center |
Topics (in Japanese) |
(See Japanese page) |
Topics (in English) |
Simulation Technique, etc. |
Paper Information |
Registration To |
EST |
Conference Code |
2020-01-EST |
Language |
Japanese |
Title (in Japanese) |
(See Japanese page) |
Sub Title (in Japanese) |
(See Japanese page) |
Title (in English) |
Evaluation of nerve response in a mouse model by temporal interference stimulation |
Sub Title (in English) |
|
Keyword(1) |
tACS |
Keyword(2) |
transcranial Temporal Interference Stimulation |
Keyword(3) |
Mouse Model |
Keyword(4) |
Deep Brain Region |
Keyword(5) |
SPFD |
Keyword(6) |
Nerve Model |
Keyword(7) |
|
Keyword(8) |
|
1st Author's Name |
Akihiro Asai |
1st Author's Affiliation |
Nagoya Institue of Technology (NITech) |
2nd Author's Name |
Gomez-Tames Jose |
2nd Author's Affiliation |
Nagoya Institue of Technology (NITech) |
3rd Author's Name |
Akimasa Hirata |
3rd Author's Affiliation |
Nagoya Institue of Technology (NITech) |
4th Author's Name |
|
4th Author's Affiliation |
() |
5th Author's Name |
|
5th Author's Affiliation |
() |
6th Author's Name |
|
6th Author's Affiliation |
() |
7th Author's Name |
|
7th Author's Affiliation |
() |
8th Author's Name |
|
8th Author's Affiliation |
() |
9th Author's Name |
|
9th Author's Affiliation |
() |
10th Author's Name |
|
10th Author's Affiliation |
() |
11th Author's Name |
|
11th Author's Affiliation |
() |
12th Author's Name |
|
12th Author's Affiliation |
() |
13th Author's Name |
|
13th Author's Affiliation |
() |
14th Author's Name |
|
14th Author's Affiliation |
() |
15th Author's Name |
|
15th Author's Affiliation |
() |
16th Author's Name |
|
16th Author's Affiliation |
() |
17th Author's Name |
|
17th Author's Affiliation |
() |
18th Author's Name |
|
18th Author's Affiliation |
() |
19th Author's Name |
|
19th Author's Affiliation |
() |
20th Author's Name |
|
20th Author's Affiliation |
() |
Speaker |
Author-1 |
Date Time |
2020-01-30 15:15:00 |
Presentation Time |
25 minutes |
Registration for |
EST |
Paper # |
EST2019-88 |
Volume (vol) |
vol.119 |
Number (no) |
no.407 |
Page |
pp.51-56 |
#Pages |
6 |
Date of Issue |
2020-01-23 (EST) |
|