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Paper Abstract and Keywords
Presentation 2019-04-18 15:45
Construction of an artificial cell membrane device and its application to a sensor for drug side effects
Ayumi Hirano-Iwata, Daisuke Tadaki, Daichi Yamaura, Miki Kato, Maki Komiya (Tohoku Univ.), Haruka Inoue, Yuzuru Tozawa (Saitama Univ.), Teng Ma, Hideaki Yamamoto (Tohoku Univ.), Michio Niwano (Tohoku Fukushi Univ.)   エレソ技報アーカイブはこちら
Abstract (in Japanese) (See Japanese page) 
(in English) Ion channel proteins are membrane proteins that regulate ion flows across cell membranes and have attracted attention not only as primary molecular targets for drug actions but also as major targets for drug-induced side effects. Reconstitution of ion channel proteins in artificial bilayer lipid membranes (BLMs) provides an excellent system for drug screenings. The advantage of this system is its versatility in terms of producing target channels, including those prepared by cell-free protein expression systems, in which pure proteins of various channel genotypes can be produced directly from a protein-encoding plasmid. However, the BLM system suffers from low experimental efficiency due to instability of the BLMs and difficulty in ion channel incorporation into BLMs. In this presentation, we will show you our recent approaches for addressing these issues based on nano- and micro-fabrication. Our approach leads to the realization of a BLM-based high-throughput platform for screening the effects of drugs that act on various ion channel genotypes.
Keyword (in Japanese) (See Japanese page) 
(in English) ion channel / lipid bilayer / cell-free protein synthesis / silicon microfabrication / drug screening / / /  
Reference Info. IEICE Tech. Rep., vol. 119, no. 9, ED2019-7, pp. 23-26, April 2019.
Paper # ED2019-7 
Date of Issue 2019-04-11 (ED) 
ISSN Print edition: ISSN 0913-5685  Online edition: ISSN 2432-6380

Conference Information
Committee ED  
Conference Date 2019-04-18 - 2019-04-18 
Place (in Japanese) (See Japanese page) 
Place (in English) RIEC, Tohoku Univ. 
Topics (in Japanese) (See Japanese page) 
Topics (in English) Organic devices, oxide devices, general 
Paper Information
Registration To ED 
Conference Code 2019-04-ED 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Construction of an artificial cell membrane device and its application to a sensor for drug side effects 
Sub Title (in English)  
Keyword(1) ion channel  
Keyword(2) lipid bilayer  
Keyword(3) cell-free protein synthesis  
Keyword(4) silicon microfabrication  
Keyword(5) drug screening  
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1st Author's Name Ayumi Hirano-Iwata  
1st Author's Affiliation Tohoku University (Tohoku Univ.)
2nd Author's Name Daisuke Tadaki  
2nd Author's Affiliation Tohoku University (Tohoku Univ.)
3rd Author's Name Daichi Yamaura  
3rd Author's Affiliation Tohoku University (Tohoku Univ.)
4th Author's Name Miki Kato  
4th Author's Affiliation Tohoku University (Tohoku Univ.)
5th Author's Name Maki Komiya  
5th Author's Affiliation Tohoku University (Tohoku Univ.)
6th Author's Name Haruka Inoue  
6th Author's Affiliation Saitama University (Saitama Univ.)
7th Author's Name Yuzuru Tozawa  
7th Author's Affiliation Saitama University (Saitama Univ.)
8th Author's Name Teng Ma  
8th Author's Affiliation Tohoku University (Tohoku Univ.)
9th Author's Name Hideaki Yamamoto  
9th Author's Affiliation Tohoku University (Tohoku Univ.)
10th Author's Name Michio Niwano  
10th Author's Affiliation Tohoku Fukushi University (Tohoku Fukushi Univ.)
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Speaker
Date Time 2019-04-18 15:45:00 
Presentation Time 25 
Registration for ED 
Paper # IEICE-ED2019-7 
Volume (vol) IEICE-119 
Number (no) no.9 
Page pp.23-26 
#Pages IEICE-4 
Date of Issue IEICE-ED-2019-04-11 


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