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Paper Abstract and Keywords
Presentation 2018-11-23 10:25
A physiologically based State Transition Model between Wake, REM-sleep and non-REM-sleep state
Kazuya Hirota, Yasuhiro Tsubo (Ritsumeikan Univ.) CCS2018-40
Abstract (in Japanese) (See Japanese page) 
(in English) A sleep-wake rhythm is a biological rhythm with a roughly 24-hour period and widely observed in animals. This rhythm consists of two cycles. One is a long cycle with state transitions between wake state and sleep state and the other is a short cycle with state transitions between rapid eye movement (REM) sleep state and non-REM sleep state within a sleep state. It has been reported that a neuropeptide, Orexin, plays an important role in regulating the sleep-wake rhythm, and the deficient of Orexin causes an irregular sleep-wake rhythm similar to a sleep disorder called narcolepsy. It is, however, not fully understood how Orexin controls the sleep-wake rhythm. Recently, while several mathematical models describing the role of Orexin in regulating the sleep-wake rhythms have been proposed, any previous model with the dynamics of an Orexinergic neuronal population couldn't reproduce three-state transition among wake state, REM sleep state, and NREM sleep state. Fulcher et al. (2014) introduced a mathematical model which describes dynamics of Orexinergic neuronal population and shows two state transition between wake state and sleep state. On the other hand, Diniz Behn et al. (2013) introduced a model called MI model which describes another state transition between REM sleep state and NREM sleep state. In this study, we proposed a mathematical model by combining Fulcher et al.'s Model and MI model of Diniz Behn et al.. We demonstrated that our model can reproduce the features of Orexin deficiency obtained by previous physiological experiments: increasing the number of occurrences of REM sleep, inducing the frequent transition from wake state to REM sleep state, decreasing appearance time and duration of wake state, increasing appearance time and duration of REM sleep state.
Keyword (in Japanese) (See Japanese page) 
(in English) Sleep / Orexin / Narcolepsy / Mathematical model / / / /  
Reference Info. IEICE Tech. Rep., vol. 118, no. 316, CCS2018-40, pp. 39-44, Nov. 2018.
Paper # CCS2018-40 
Date of Issue 2018-11-15 (CCS) 
ISSN Print edition: ISSN 0913-5685  Online edition: ISSN 2432-6380
Download PDF CCS2018-40

Conference Information
Committee CCS  
Conference Date 2018-11-22 - 2018-11-23 
Place (in Japanese) (See Japanese page) 
Place (in English) Kobe Univ. 
Topics (in Japanese) (See Japanese page) 
Topics (in English) Interaction and Communication, etc. 
Paper Information
Registration To CCS 
Conference Code 2018-11-CCS 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) A physiologically based State Transition Model between Wake, REM-sleep and non-REM-sleep state 
Sub Title (in English)  
Keyword(1) Sleep  
Keyword(2) Orexin  
Keyword(3) Narcolepsy  
Keyword(4) Mathematical model  
1st Author's Name Kazuya Hirota  
1st Author's Affiliation Ritsumeikan University (Ritsumeikan Univ.)
2nd Author's Name Yasuhiro Tsubo  
2nd Author's Affiliation Ritsumeikan University (Ritsumeikan Univ.)
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Date Time 2018-11-23 10:25:00 
Presentation Time 25 
Registration for CCS 
Paper # IEICE-CCS2018-40 
Volume (vol) IEICE-118 
Number (no) no.316 
Page pp.39-44 
#Pages IEICE-6 
Date of Issue IEICE-CCS-2018-11-15 

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