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Paper Abstract and Keywords
Presentation 2018-02-20 10:45
Detection of Differentiated vs. Undifferentiated Colonies of iPS Cells Using CNN for Regression on Class Probability
Kojiro Tanaka, Bisser Raytchev, Takio Kurita, Toru Tamaki, Kazufumi Kaneda (Hiroshima Univ.) PRMU2017-164 CNR2017-42
Abstract (in Japanese) (See Japanese page) 
(in English) Induced pluripotent stem(iPS) cells, which have the ability to differentiate into any other cell type in the body, are already revolutionizing medical therapy. Since a large number of undifferentiated human iPS cells must be prepared for use, the development of an automated culture system for iPS cells is considered to be crucial. Among the multiple procedures involve in the culture system, detection of good/bad cells and the subsequent elimination of bad cells appears to be one of the most important parts. In this paper we propose a method for detection of good/bad colonies of iPS cells by semantic segmentation. Instead of assigning a single class label to the whole patch, we divide local patches into sub-areas and calculate probability mass function(pmf) for each sub-area to preserve structural information, then learning is carried out by regression rather than classification. Experimental result on two dataset show that a CNN using the proposed method outperforms a classification-based CNN.
Keyword (in Japanese) (See Japanese page) 
(in English) iPS cells / regression / structural information / semantic segmentation / CNN / / /  
Reference Info. IEICE Tech. Rep., vol. 117, no. 442, PRMU2017-164, pp. 109-114, Feb. 2018.
Paper # PRMU2017-164 
Date of Issue 2018-02-12 (PRMU, CNR) 
ISSN Print edition: ISSN 0913-5685    Online edition: ISSN 2432-6380
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All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
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Conference Information
Committee PRMU CNR  
Conference Date 2018-02-19 - 2018-02-20 
Place (in Japanese) (See Japanese page) 
Place (in English)  
Topics (in Japanese) (See Japanese page) 
Topics (in English)  
Paper Information
Registration To PRMU 
Conference Code 2018-02-PRMU-CNR 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Detection of Differentiated vs. Undifferentiated Colonies of iPS Cells Using CNN for Regression on Class Probability 
Sub Title (in English)  
Keyword(1) iPS cells  
Keyword(2) regression  
Keyword(3) structural information  
Keyword(4) semantic segmentation  
Keyword(5) CNN  
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1st Author's Name Kojiro Tanaka  
1st Author's Affiliation Hiroshima University (Hiroshima Univ.)
2nd Author's Name Bisser Raytchev  
2nd Author's Affiliation Hiroshima University (Hiroshima Univ.)
3rd Author's Name Takio Kurita  
3rd Author's Affiliation Hiroshima University (Hiroshima Univ.)
4th Author's Name Toru Tamaki  
4th Author's Affiliation Hiroshima University (Hiroshima Univ.)
5th Author's Name Kazufumi Kaneda  
5th Author's Affiliation Hiroshima University (Hiroshima Univ.)
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Speaker Author-1 
Date Time 2018-02-20 10:45:00 
Presentation Time 30 minutes 
Registration for PRMU 
Paper # PRMU2017-164, CNR2017-42 
Volume (vol) vol.117 
Number (no) no.442(PRMU), no.443(CNR) 
Page pp.109-114 
#Pages
Date of Issue 2018-02-12 (PRMU, CNR) 


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