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Paper Abstract and Keywords
Presentation 2018-02-19 14:55
Multiscale Analysis of Skin Tissues in Clinical Study and Verification by Echo Simulation
Masaaki Omura, Kenji Yoshida, Tamaki Honda, Shinsuke Akita, Ichiro Manabe, Tadashi Yamaguchi (Chiba Univ.) US2017-116
Abstract (in Japanese) (See Japanese page) 
(in English) The goal of this study is to develop a quantitative ultrasound (QUS) method for diagnosing skin fibrosis or inflammation at the early stage of lymphedema. In this report, we characterized ex-vivo normal skin (n=3) and lymphedema skin (n=1) samples. RF echo signals were acquired using a self-made ultrasonic scanner with a 15 MHz and 25 MHz single element concave transducer. Moreover, we applied the signal analysis method using the echo amplitude envelope and the backscatter coefficient (BSC) to assess the conditions of collagen fibers. QUS parameters were clustering parameter $mu$ and diffuse to total signal power ratio parameter 1/($kappa$+1) of Homodyned-K distribution, and integrated BSC (IB) that indicates the intensity of backscattered echo signals. The median (25-75 percentiles) of calculated QUS parameters with 25 MHz transducer is below: $mu$ = 0.71 (0.43-1.16), IB = 4.32 (2.20-10.3)×10^{-3 }sr^{-1} mm^{-1} in the normal skin, and $mu$ = 2.03 (1.32-2.89), IB = 13.0 (6.49-23.4)×10^{-3 }sr^{-1} mm^{-1} in the lymphedema skin. It is considered that the number density of collagen fibers in the lymphedema dermis is higher, and its backscattered signal is more hyperechoic than normal dermis tissues due to skin fibrosis. This result in lymphedema skin was verified by computer simulation reflecting high number density with collagen fibers.
Keyword (in Japanese) (See Japanese page) 
(in English) Tissue Characterization / Multiscale / Echo Signal Analysis Method / Simulation / Skin Tissues / / /  
Reference Info. IEICE Tech. Rep., vol. 117, no. 441, US2017-116, pp. 25-30, Feb. 2018.
Paper # US2017-116 
Date of Issue 2018-02-12 (US) 
ISSN Print edition: ISSN 0913-5685  Online edition: ISSN 2432-6380
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (No. 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
Download PDF US2017-116

Conference Information
Committee US  
Conference Date 2018-02-19 - 2018-02-19 
Place (in Japanese) (See Japanese page) 
Place (in English)  
Topics (in Japanese) (See Japanese page) 
Topics (in English)  
Paper Information
Registration To US 
Conference Code 2018-02-US 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Multiscale Analysis of Skin Tissues in Clinical Study and Verification by Echo Simulation 
Sub Title (in English)  
Keyword(1) Tissue Characterization  
Keyword(2) Multiscale  
Keyword(3) Echo Signal Analysis Method  
Keyword(4) Simulation  
Keyword(5) Skin Tissues  
1st Author's Name Masaaki Omura  
1st Author's Affiliation Chiba University (Chiba Univ.)
2nd Author's Name Kenji Yoshida  
2nd Author's Affiliation Chiba University (Chiba Univ.)
3rd Author's Name Tamaki Honda  
3rd Author's Affiliation Chiba University (Chiba Univ.)
4th Author's Name Shinsuke Akita  
4th Author's Affiliation Chiba University (Chiba Univ.)
5th Author's Name Ichiro Manabe  
5th Author's Affiliation Chiba University (Chiba Univ.)
6th Author's Name Tadashi Yamaguchi  
6th Author's Affiliation Chiba University (Chiba Univ.)
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Date Time 2018-02-19 14:55:00 
Presentation Time 25 
Registration for US 
Paper # IEICE-US2017-116 
Volume (vol) IEICE-117 
Number (no) no.441 
Page pp.25-30 
#Pages IEICE-6 
Date of Issue IEICE-US-2018-02-12 

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