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Paper Abstract and Keywords
Presentation 2017-11-24 14:55
Extracellular diffusion analysis in the mouse cortex using in vivo integrative optical imaging method
Yui Hiroya, Kenya Tanaka, Yuto Yoshida (Tohoku Univ.), Akihiro Karashima (TOHTECH), Mitsuyuki Nakao, Norihiro Katayama (Tohoku Univ.) MBE2017-47
Abstract (in Japanese) (See Japanese page) 
(in English) The brain has an unique waste clearance system, called glymphatic system, which is activated during sleep state. In order to know the mechanism of the state-dependency of the system, various methods were applied to measure diffusion property of brain parenchyma. However, the mechanism is still unknown due to the low time resolution of those methods. In this study, by using repetitive integrative optical imaging method, we measured the diffusion property of brain parenchyma in the primary somatosensory cortex of a mouse under the isoflurane anesthetized condition. As a result, we found that there is a drift of diffusion in brain parenchyma. In addition, we found weak correlation between variance of EEG and diffusion coefficient. These results suggest that directed cerebrospinal fluid flows in the brain and the diffusion property changes depending on the concentration of anesthesia.
Keyword (in Japanese) (See Japanese page) 
(in English) Glymphatic system / Extracellular space / Integrative Optical Imaging / / / / /  
Reference Info. IEICE Tech. Rep., vol. 117, no. 324, MBE2017-47, pp. 5-8, Nov. 2017.
Paper # MBE2017-47 
Date of Issue 2017-11-17 (MBE) 
ISSN Print edition: ISSN 0913-5685    Online edition: ISSN 2432-6380
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All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
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Conference Information
Committee MBE NC  
Conference Date 2017-11-24 - 2017-11-25 
Place (in Japanese) (See Japanese page) 
Place (in English) Tohoku University 
Topics (in Japanese) (See Japanese page) 
Topics (in English) BCI/BMI, generall 
Paper Information
Registration To MBE 
Conference Code 2017-11-MBE-NC 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Extracellular diffusion analysis in the mouse cortex using in vivo integrative optical imaging method 
Sub Title (in English)  
Keyword(1) Glymphatic system  
Keyword(2) Extracellular space  
Keyword(3) Integrative Optical Imaging  
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1st Author's Name Yui Hiroya  
1st Author's Affiliation Tohoku University (Tohoku Univ.)
2nd Author's Name Kenya Tanaka  
2nd Author's Affiliation Tohoku University (Tohoku Univ.)
3rd Author's Name Yuto Yoshida  
3rd Author's Affiliation Tohoku University (Tohoku Univ.)
4th Author's Name Akihiro Karashima  
4th Author's Affiliation Tohoku Institute of Technology (TOHTECH)
5th Author's Name Mitsuyuki Nakao  
5th Author's Affiliation Tohoku University (Tohoku Univ.)
6th Author's Name Norihiro Katayama  
6th Author's Affiliation Tohoku University (Tohoku Univ.)
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Speaker Author-1 
Date Time 2017-11-24 14:55:00 
Presentation Time 25 minutes 
Registration for MBE 
Paper # MBE2017-47 
Volume (vol) vol.117 
Number (no) no.324 
Page pp.5-8 
#Pages
Date of Issue 2017-11-17 (MBE) 


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