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Paper Abstract and Keywords
Presentation 2017-03-14 15:25
Statistical Integrative Analysis of MicroRNA and Gene
Takuya Oki, Yutaka Fukuoka (Kogakuin Univ.), Tomohiro Umezu, Junko Ohyashiki (Tokyo Med Univ.) MBE2016-101
Abstract (in Japanese) (See Japanese page) 
(in English) A microRNA (miRNA), which is a non-cording RNA, regulates genes, and recently its role in cancer attracts attention. Therefore, the number of studies on expression levels of miRNAs in cancer cells is increasing. Results of integrative analyses of miRNAs and mRNAs are largely affected by the size of the data used for the analysis. For a small sized data set, the numbers of significantly altered miRNAs and mRNAs tend to be small, indicating that no meaningful results are obtained. This study proposed a method for such small sized data sets. This method compared target genes of a miRNA as a group with randomly selected genes (back ground genes). We performed simulations to investigate the effectiveness of the proposed method. The simulation results indicated that the statistics used in the proposed method reflected the differences in the simulated data. Then, we applied it to real cancer data. Some groups of genes having functions related to cancer were extracted as significantly altered. These results suggest the effectiveness of the proposed the method.
Keyword (in Japanese) (See Japanese page) 
(in English) MicroRNA (MiRNA) / Gene (MRNA) / Integrative Analysis / Cancer / / / /  
Reference Info. IEICE Tech. Rep., vol. 116, no. 520, MBE2016-101, pp. 91-94, March 2017.
Paper # MBE2016-101 
Date of Issue 2017-03-06 (MBE) 
ISSN Print edition: ISSN 0913-5685  Online edition: ISSN 2432-6380
Copyright
and
reproduction
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (No. 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
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Conference Information
Committee MBE NC  
Conference Date 2017-03-13 - 2017-03-14 
Place (in Japanese) (See Japanese page) 
Place (in English) Kikai-Shinko-Kaikan Bldg. 
Topics (in Japanese) (See Japanese page) 
Topics (in English)  
Paper Information
Registration To MBE 
Conference Code 2017-03-MBE-NC 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Statistical Integrative Analysis of MicroRNA and Gene 
Sub Title (in English)  
Keyword(1) MicroRNA (MiRNA)  
Keyword(2) Gene (MRNA)  
Keyword(3) Integrative Analysis  
Keyword(4) Cancer  
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1st Author's Name Takuya Oki  
1st Author's Affiliation Kogakuin University (Kogakuin Univ.)
2nd Author's Name Yutaka Fukuoka  
2nd Author's Affiliation Kogakuin University (Kogakuin Univ.)
3rd Author's Name Tomohiro Umezu  
3rd Author's Affiliation Tokyo Medical University (Tokyo Med Univ.)
4th Author's Name Junko Ohyashiki  
4th Author's Affiliation Tokyo Medical University (Tokyo Med Univ.)
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Speaker
Date Time 2017-03-14 15:25:00 
Presentation Time 25 
Registration for MBE 
Paper # IEICE-MBE2016-101 
Volume (vol) IEICE-116 
Number (no) no.520 
Page pp.91-94 
#Pages IEICE-4 
Date of Issue IEICE-MBE-2017-03-06 


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