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Paper Abstract and Keywords
Presentation 2017-03-14 10:00
Low-frequency (1-4 Hz) preferences to AC electric fields in rat hippocampal CA1 pyramdal neurons
Kenya Innami (Tokyo Tech), Masashi Inoue, Hiroyoshi Miyakawa (TUPLS), Toru Aonishi (Tokyo Tech) NC2016-87
Abstract (in Japanese) (See Japanese page) 
(in English) It has been proposed that extracellular electric fields play essential roles for information processing in the mammalian brain. Previously we have reported the roles of DC electric fields for modifying neural activities of CA1 pyramidal neurons by using rat hippocampal slices. Here, we have determined the effect of applied extracellular AC electric fields on somatic membrane potentials in the CA1 pyramidal neurons by using the whole-cell patch clamp method.
CA1 pyramidal neurons have exhibited robust oscillations of membrane potentials in response to the applied 1-32 Hz AC field. Subsequent analyses of frequency preferences have revealed that the membrane potential amplitudes were larger at the range of 1 - 4 Hz, and the amplitudes were smaller at the higher frequency from 8 to 32 Hz. Relationship between the electric field intensity and the subthreshold membrane potential amplitude of the responses was almost linear and the slope was 0.4 mm in response to 2 Hz AC fields. Peak times of the membrane potential responses have shown significant delays from the peaks of the electric fields at all tested frequencies. The extent of the delay varied among the tested cells. These results suggest that the CA1 pyramidal neurons behave as passive elements possessing low-pass filters to the AC fields and that fluctuations of the timing and/or synchronizations of the action potentials may be produced with these response characteristic to the AC fields.
Keyword (in Japanese) (See Japanese page) 
(in English) Arduino / fluctuation / whole-cell patch clamp / hippocampal slice / phase shift / / /  
Reference Info. IEICE Tech. Rep., vol. 116, no. 521, NC2016-87, pp. 137-142, March 2017.
Paper # NC2016-87 
Date of Issue 2017-03-06 (NC) 
ISSN Print edition: ISSN 0913-5685  Online edition: ISSN 2432-6380
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
Download PDF NC2016-87

Conference Information
Committee MBE NC  
Conference Date 2017-03-13 - 2017-03-14 
Place (in Japanese) (See Japanese page) 
Place (in English) Kikai-Shinko-Kaikan Bldg. 
Topics (in Japanese) (See Japanese page) 
Topics (in English)  
Paper Information
Registration To NC 
Conference Code 2017-03-MBE-NC 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Low-frequency (1-4 Hz) preferences to AC electric fields in rat hippocampal CA1 pyramdal neurons 
Sub Title (in English)  
Keyword(1) Arduino  
Keyword(2) fluctuation  
Keyword(3) whole-cell patch clamp  
Keyword(4) hippocampal slice  
Keyword(5) phase shift  
1st Author's Name Kenya Innami  
1st Author's Affiliation Tokyo Institute of Technology (Tokyo Tech)
2nd Author's Name Masashi Inoue  
2nd Author's Affiliation Tokyo University of Pharmacy and Life Sciences (TUPLS)
3rd Author's Name Hiroyoshi Miyakawa  
3rd Author's Affiliation Tokyo University of Pharmacy and Life Sciences (TUPLS)
4th Author's Name Toru Aonishi  
4th Author's Affiliation Tokyo Institute of Technology (Tokyo Tech)
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Date Time 2017-03-14 10:00:00 
Presentation Time 25 
Registration for NC 
Paper # IEICE-NC2016-87 
Volume (vol) IEICE-116 
Number (no) no.521 
Page pp.137-142 
#Pages IEICE-6 
Date of Issue IEICE-NC-2017-03-06 

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