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| Presentation | 2015-11-20 16:00 [Invited Talk] Non-invasive analysis of the whole brain neuronal activity using MRI -- from fundamental to application -- Makoto Osanai (Tohoku Univ.)  MBE2015-55 NC2015-39 |
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| Abstract | (in Japanese) | (See Japanese page) |
| (in English) | Recently, visualization of the dynamics of intracellular Ca^{2+} increased by the neuronal action potentials (Ca^{2+} imaging) has been widely used for raveling the functions of the nervous systems. The Ca^{2+} imaging can record the multicellular activities simultaneously, however, it can hardly visualize the whole brain activities. Thus, for visualizing the whole brain activities, we used one MRI technique, activation-induced manganese-enhanced MRI (AIM-MRI), which is based on the use of Mn^{2+} as a surrogate marker of Ca^{2+} influx. Therefore, it is known that AIM-MRI can measure the history of the neuronal activities in whole brain. After confirmation of the dependency of Mn^{2+} accumulation to neuronal activity, we demonstrated that AIM-MRI with quantitative determination of the longitudinal relaxation time (qAIM-MRI) reveals the severity of Parkinson’s disease (PD) in mice. A highly active region was then observed by qAIM-MRI in the caudate-putamen in PD-model mice that was significantly correlated to the severity of PD, suggesting its involvement in the expression of PD symptoms. Our results provide a foundation for the development and application of quantitative activity mapping in the entire brain using qAIM-MRI for the study and diagnosis of various neurological disorders. | |
| Keyword | (in Japanese) | (See Japanese page) |
| (in English) | Brain / Nervous system / Neurological disorder / Calcium / Manganese / Imaging / MRI / Parkinson’s disease | |
| Reference Info. | IEICE Tech. Rep., vol. 115, no. 318, NC2015-39, pp. 19-19, Nov. 2015. | |
| Paper # | NC2015-39 | |
| Date of Issue | 2015-11-13 (MBE, NC) | |
| ISSN | Print edition: ISSN 0913-5685 Online edition: ISSN 2432-6380 | |
| Copyright and reproduction |
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034) | |
| Download PDF | MBE2015-55 NC2015-39 |
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| Conference Information | |
| Committee | MBE NC |
| Conference Date | 2015-11-20 - 2015-11-21 |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | Tohoku University |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
| Paper Information | |
| Registration To | NC |
| Conference Code | 2015-11-MBE-NC |
| Language | Japanese |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Non-invasive analysis of the whole brain neuronal activity using MRI |
| Sub Title (in English) | from fundamental to application |
| Keyword(1) | Brain |
| Keyword(2) | Nervous system |
| Keyword(3) | Neurological disorder |
| Keyword(4) | Calcium |
| Keyword(5) | Manganese |
| Keyword(6) | Imaging |
| Keyword(7) | MRI |
| Keyword(8) | Parkinson’s disease |
| 1st Author's Name | Makoto Osanai |
| 1st Author's Affiliation | Tohoku University (Tohoku Univ.) |
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| Speaker | Author-1 |
| Date Time | 2015-11-20 16:00:00 |
| Presentation Time | 60 minutes |
| Registration for | NC |
| Paper # | MBE2015-55, NC2015-39 |
| Volume (vol) | vol.115 |
| Number (no) | no.317(MBE), no.318(NC) |
| Page | p.15(MBE), p.19(NC) |
| #Pages | 1 |
| Date of Issue | 2015-11-13 (MBE, NC) |
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