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Paper Abstract and Keywords
Presentation 2014-06-13 14:45
A study on the method to initiate the pacemaker activity based on the bifurcation analysis of a human ventricular cell model
Yoshiki Ogawa, Shinji Doi (Kyoto Univ.) MBE2014-23
Abstract (in Japanese) (See Japanese page) 
(in English) Electronic pacemakers play an important role in the treatment of bradyarrhythmia. Recently, different strategies to initiate pacemaker activity by genetic modification of ionic currents across the cell membrane were developed. These new approaches are called biological pacemaker engineering. Recent studies on the creation of the biological pacemaker using mathematical cell models have revealed the mechanism of induction of pacemaker activity. However, these studies have used the models of a guinea pig ventricular myocyte. In this paper, we use the reduced Ten Tusscher-Noble-Noble-Panfilov model of human ventricular myocytes. We analyze the bifurcation structure of the model by varying conductances of ion channels, and examine the method to initiate pacemaking. We also consider the effects of various ionic currents on the pacemaker activity.
Keyword (in Japanese) (See Japanese page) 
(in English) biological pacemaker engineering / ventricular cell model / bifurcation analysis / ionic current / / / /  
Reference Info. IEICE Tech. Rep., vol. 114, no. 79, MBE2014-23, pp. 51-55, June 2014.
Paper # MBE2014-23 
Date of Issue 2014-06-06 (MBE) 
ISSN Print edition: ISSN 0913-5685  Online edition: ISSN 2432-6380
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
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Conference Information
Committee MBE  
Conference Date 2014-06-13 - 2014-06-13 
Place (in Japanese) (See Japanese page) 
Place (in English) Hokkaido Univerisity 
Topics (in Japanese) (See Japanese page) 
Topics (in English)  
Paper Information
Registration To MBE 
Conference Code 2014-06-MBE 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) A study on the method to initiate the pacemaker activity based on the bifurcation analysis of a human ventricular cell model 
Sub Title (in English)  
Keyword(1) biological pacemaker engineering  
Keyword(2) ventricular cell model  
Keyword(3) bifurcation analysis  
Keyword(4) ionic current  
1st Author's Name Yoshiki Ogawa  
1st Author's Affiliation Kyoto University (Kyoto Univ.)
2nd Author's Name Shinji Doi  
2nd Author's Affiliation Kyoto University (Kyoto Univ.)
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Date Time 2014-06-13 14:45:00 
Presentation Time 25 
Registration for MBE 
Paper # IEICE-MBE2014-23 
Volume (vol) IEICE-114 
Number (no) no.79 
Page pp.51-55 
#Pages IEICE-5 
Date of Issue IEICE-MBE-2014-06-06 

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