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Paper Abstract and Keywords
Presentation 2013-05-24 17:40
[Poster Presentation] Effect of Ghrelin on hypothalamic tuberomammillary nucleus neurons
Yuji Wakabayashi, Juhyon Kim, Kazuki Nakajima (Univ. of Toyama)
Abstract (in Japanese) (See Japanese page) 
(in English) Ghrelin, which is produced in the brain and stomach, is an endogenous ligand of the growth hormone secretagogue receptor (GHS-R). Ghrelin participates in regulation of GH release and food intake. Recent study demonstrated that ghrelin also participates in regulation of sleep-wakefulness. Tuberomammillary nucleus (TMN), which is one of brain sites that control sleep-wakefulness, also expresses GHS-R. However, effect of ghrelin on TMN neurons is remained unclear. Thus, we examined effects of ghrelin on TMN neurons using rat brain slice preparations and whole-cell patch clamp recording technique. Application of ghrelin depolarized TMN neurons and ghrelin-induced depolarization was also observed under presence of tetrodotoxin. These results suggest that ghrelin depolarizes TMN neurons and participates in the regulation of sleep-wakefulness by stimulated activity of TMN neurons.
Keyword (in Japanese) (See Japanese page) 
(in English) Ghrelin / Tuberomammillary nucleus / Depolarization / / / / /  
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Conference Information
Committee BioX  
Conference Date 2013-05-24 - 2013-05-24 
Place (in Japanese) (See Japanese page) 
Place (in English) Toyama Prefectural University 
Topics (in Japanese) (See Japanese page) 
Topics (in English) Workshop for student, Biometrics, etc. 
Paper Information
Registration To BioX 
Conference Code 2013-05-BioX 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Effect of Ghrelin on hypothalamic tuberomammillary nucleus neurons 
Sub Title (in English)  
Keyword(1) Ghrelin  
Keyword(2) Tuberomammillary nucleus  
Keyword(3) Depolarization  
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1st Author's Name Yuji Wakabayashi  
1st Author's Affiliation University of Toyama (Univ. of Toyama)
2nd Author's Name Juhyon Kim  
2nd Author's Affiliation University of Toyama (Univ. of Toyama)
3rd Author's Name Kazuki Nakajima  
3rd Author's Affiliation University of Toyama (Univ. of Toyama)
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Date Time 2013-05-24 17:40:00 
Presentation Time 80 minutes 
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Volume (vol) vol.113 
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