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Paper Abstract and Keywords
Presentation 2013-01-24 11:05
Performance improvements using MRI anatomical normalization in statistical comparison of brain FDG-PET for dementia diagnosis
Ryosuke Mizuno (Chiba Univ./TMIG), Muneyuki Sakata, Kenji Ishii, Keiichi Oda, Jun Toyohara, Kiichi Ishiwata (TMIG), Yuichi Kimura (NIRS/Chiba Univ.) MI2012-66
Abstract (in Japanese) (See Japanese page) 
(in English) Statistical comparisons to detect significant decreases of glucose metabolism in brain images of positron emission tomography (PET) using [18F]fluorodeoxyglucose (FDG) are frequently used for dementia diagnosis. However, the results of the statistical comparisons are often affected by the inconsistency of the anatomical normalization. In this study, we employed more accurate method for anatomical normalization with MRI, and compared the performance with that of the ordinary method using clinical images including healthy elderly subjects. Our proposed method markedly reduced false positive signals, and was detected hypoglucose-metabolic regions where could not be detected by the ordinary method. The findings suggested that our method has been improved the performance of the diagnosis.
Keyword (in Japanese) (See Japanese page) 
(in English) dementia / FDG / PET / MRI / anatomical normalization / statistical comparisons / /  
Reference Info. IEICE Tech. Rep., vol. 112, no. 411, MI2012-66, pp. 25-29, Jan. 2013.
Paper # MI2012-66 
Date of Issue 2013-01-17 (MI) 
ISSN Print edition: ISSN 0913-5685  Online edition: ISSN 2432-6380
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (No. 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
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Conference Information
Committee MI  
Conference Date 2013-01-24 - 2013-01-25 
Place (in Japanese) (See Japanese page) 
Place (in English) Bunka Tenbusu Kan 
Topics (in Japanese) (See Japanese page) 
Topics (in English) Computational anatomy and its application to computer assisted diagnosis and therapy, etc 
Paper Information
Registration To MI 
Conference Code 2013-01-MI 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Performance improvements using MRI anatomical normalization in statistical comparison of brain FDG-PET for dementia diagnosis 
Sub Title (in English)  
Keyword(1) dementia  
Keyword(2) FDG  
Keyword(3) PET  
Keyword(4) MRI  
Keyword(5) anatomical normalization  
Keyword(6) statistical comparisons  
1st Author's Name Ryosuke Mizuno  
1st Author's Affiliation Chiba University/Tokyo Metropolitan Institute of Gerontology (Chiba Univ./TMIG)
2nd Author's Name Muneyuki Sakata  
2nd Author's Affiliation Tokyo Metropolitan Institute of Gerontology (TMIG)
3rd Author's Name Kenji Ishii  
3rd Author's Affiliation Tokyo Metropolitan Institute of Gerontology (TMIG)
4th Author's Name Keiichi Oda  
4th Author's Affiliation Tokyo Metropolitan Institute of Gerontology (TMIG)
5th Author's Name Jun Toyohara  
5th Author's Affiliation Tokyo Metropolitan Institute of Gerontology (TMIG)
6th Author's Name Kiichi Ishiwata  
6th Author's Affiliation Tokyo Metropolitan Institute of Gerontology (TMIG)
7th Author's Name Yuichi Kimura  
7th Author's Affiliation National Institute of Radiological Sciences/Chiba University (NIRS/Chiba Univ.)
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Date Time 2013-01-24 11:05:00 
Presentation Time 15 
Registration for MI 
Paper # IEICE-MI2012-66 
Volume (vol) IEICE-112 
Number (no) no.411 
Page pp.25-29 
#Pages IEICE-5 
Date of Issue IEICE-MI-2013-01-17 

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