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| Presentation | 2011-07-24 11:30 [Invited Talk] Gene therapy for restoring vision -- Use of genes derived from the green algae -- Hiroshi Tomita, Eriko Sugano, Hitomi Isago, Namie Murayama, Eri Koyanagi, Makoto Tamai (Tohoku Univ.)  HIP2011-37 |
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| Abstract | (in Japanese) | (See Japanese page) |
| (in English) | Channelrhodopsin-2, which is derived from the green alga Chlamydomonas reinhardtii, functions as a light-driven cation-selective channel. Because of its specific character, it is possible to make photo sensitive neurons by transfecting the ChR2 gene into neurons. Retinitis pigmentosa (RP) is one of genetic diseases results in the death of rod photoreceptors followed by gradual death of the cones. The degeneration leads to blindness. Although photoreceptor cells are often degenerated in the eyes of RP patients, other retinal neurons, including retinal ganglion cells (RGCs), are preserved. Herein, we introduce the strategies for restoring vision by using channelrhodopsins. | |
| Keyword | (in Japanese) | (See Japanese page) |
| (in English) | Retinitis pigmentosa / Gene therapy / Retinal ganglion cells / Channelrhodopsin-2 / Adeno-associated virus vector / / / | |
| Reference Info. | IEICE Tech. Rep., vol. 111, no. 155, HIP2011-37, pp. 47-50, July 2011. | |
| Paper # | HIP2011-37 | |
| Date of Issue | 2011-07-16 (HIP) | |
| ISSN | Print edition: ISSN 0913-5685 Online edition: ISSN 2432-6380 | |
| Copyright and reproduction |
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034) | |
| Download PDF | HIP2011-37 |
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| Conference Information | |
| Committee | HIP |
| Conference Date | 2011-07-23 - 2011-07-24 |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
| Paper Information | |
| Registration To | HIP |
| Conference Code | 2011-07-HIP |
| Language | Japanese |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Gene therapy for restoring vision |
| Sub Title (in English) | Use of genes derived from the green algae |
| Keyword(1) | Retinitis pigmentosa |
| Keyword(2) | Gene therapy |
| Keyword(3) | Retinal ganglion cells |
| Keyword(4) | Channelrhodopsin-2 |
| Keyword(5) | Adeno-associated virus vector |
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| Keyword(7) | |
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| 1st Author's Name | Hiroshi Tomita |
| 1st Author's Affiliation | Tohoku University (Tohoku Univ.) |
| 2nd Author's Name | Eriko Sugano |
| 2nd Author's Affiliation | Tohoku University (Tohoku Univ.) |
| 3rd Author's Name | Hitomi Isago |
| 3rd Author's Affiliation | Tohoku University (Tohoku Univ.) |
| 4th Author's Name | Namie Murayama |
| 4th Author's Affiliation | Tohoku University (Tohoku Univ.) |
| 5th Author's Name | Eri Koyanagi |
| 5th Author's Affiliation | Tohoku University (Tohoku Univ.) |
| 6th Author's Name | Makoto Tamai |
| 6th Author's Affiliation | Tohoku University (Tohoku Univ.) |
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| Speaker | Author-1 |
| Date Time | 2011-07-24 11:30:00 |
| Presentation Time | 60 minutes |
| Registration for | HIP |
| Paper # | HIP2011-37 |
| Volume (vol) | vol.111 |
| Number (no) | no.155 |
| Page | pp.47-50 |
| #Pages | 4 |
| Date of Issue | 2011-07-16 (HIP) |
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