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| Presentation | 2011-01-27 11:00 Slow-inactivation of voltage-gated Na+ current and spike firing in rat retinal neurons Sho Harabe, Tamami Motomura, Yuki Hayashida, Nobuki Murayama (Kumamoto Univ)  MBE2010-80 |
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| Abstract | (in Japanese) | (See Japanese page) |
| (in English) | Ganglion cells located at the output of vertebrate retina encode the computational results of the neural circuit into electrical spike trains, to send the information to the brain. Recent studies have shown that voltage-gated Na+ channels, which are responsible for the spike generation, exhibit inactivation with the time constants in the range between a few milliseconds and several hundred milliseconds, thereby contributing to the adaptive output of spikes. However, the slower inactivation in the time scale over seconds has not been previously analyzed in the physiological experiment. In this study, therefore, we made analyses on the transition process of the slow-inactivation of voltage-gated Na^+ current in the ganglion cells acutely dissociated from rat retinas, by means of voltage-clamp experiments with perforated-patch whole-cell mode. The results indicated that there exist the transition processes of entry into, and recovery from, inactivation with the time constants of several seconds as well as a few milliseconds. Voltage measurements under current-clamp showed that the threshold for action potential firing can be affected by the change of Na^+ current due to the inactivation. The multiple time scales of Na^+ channel inactivation are thought to contribute to history-dependent spike firings in retinal ganglion cells. |
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| Keyword | (in Japanese) | (See Japanese page) |
| (in English) | Retinal neuron / History-dependent / Na^+ channel / Inactivation / Action potential firing / / / | |
| Reference Info. | IEICE Tech. Rep., vol. 110, no. 399, MBE2010-80, pp. 9-12, Jan. 2011. | |
| Paper # | MBE2010-80 | |
| Date of Issue | 2011-01-20 (MBE) | |
| ISSN | Print edition: ISSN 0913-5685 Online edition: ISSN 2432-6380 | |
| Copyright and reproduction |
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034) | |
| Download PDF | MBE2010-80 |
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| Conference Information | |
| Committee | MBE |
| Conference Date | 2011-01-27 - 2011-01-28 |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | Kagoshima University |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | ME in general |
| Paper Information | |
| Registration To | MBE |
| Conference Code | 2011-01-MBE |
| Language | Japanese |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Slow-inactivation of voltage-gated Na+ current and spike firing in rat retinal neurons |
| Sub Title (in English) | |
| Keyword(1) | Retinal neuron |
| Keyword(2) | History-dependent |
| Keyword(3) | Na^+ channel |
| Keyword(4) | Inactivation |
| Keyword(5) | Action potential firing |
| Keyword(6) | |
| Keyword(7) | |
| Keyword(8) | |
| 1st Author's Name | Sho Harabe |
| 1st Author's Affiliation | Kumamoto University (Kumamoto Univ) |
| 2nd Author's Name | Tamami Motomura |
| 2nd Author's Affiliation | Kumamoto University (Kumamoto Univ) |
| 3rd Author's Name | Yuki Hayashida |
| 3rd Author's Affiliation | Kumamoto University (Kumamoto Univ) |
| 4th Author's Name | Nobuki Murayama |
| 4th Author's Affiliation | Kumamoto University (Kumamoto Univ) |
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| Speaker | Author-1 |
| Date Time | 2011-01-27 11:00:00 |
| Presentation Time | 25 minutes |
| Registration for | MBE |
| Paper # | MBE2010-80 |
| Volume (vol) | vol.110 |
| Number (no) | no.399 |
| Page | pp.9-12 |
| #Pages | 4 |
| Date of Issue | 2011-01-20 (MBE) |
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