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Paper Abstract and Keywords
Presentation 2011-01-20 11:30
Brain Shape Normalization in Neonatal MR Images
Aya Hashioka (Univ. of Hyogo), Syoji Kobashi, Kei Kuramoto (Univ. of Hyogo/ WPI-IFReC), Yuki Wakata, Kumiko Ando, Reiichi Ishikura (Hyogo College of Medicine), Tomomoto Ishikawa (Ishikawa Hospital), Shozo Hirota (Hyogo College of Medicine), Yutaka Hata (Univ. of Hyogo/ WPI-IFReC) MI2010-103
Abstract (in Japanese) (See Japanese page) 
(in English) In order to diagnose the cerebral diseases in the early stage, diagnosing method for neonatal brain must be studied. Voxel-based morphometry (VBM) is an approach to diagnose the cerebral diseases using MR (magnetic resonance) images. VBM normalizes the evaluating brain MR images into a template, and evaluates the distribution of gray matter density statistically. Because the template is produced from adult brain MR images, it is difficult to apply the conventional normalization to the neonatal brain. In this article, three new normalization approaches for the neonatal brain are proposed. The 1st approach defines an individual neonatal brain as a template. The 2nd approach introduces skull stripping into the 1st approach. The 3rd approach produces a neonatal template brain from some neonatal brains. Normalization accuracy was evaluated by using mutual information, position of anterior and posterior commissures (AC and PC) and angle of AC-PC line. The results in 14 neonates (revised age between -4 and 4 weeks) showed that the normalization accuracy of the 3rd approach was significantly higher than the conventional normalization and the other two approaches.
Keyword (in Japanese) (See Japanese page) 
(in English) voxel-based morphometry / MR image / neonate / brain / normalization / mutual information / anterior commissure / posterior commisure  
Reference Info. IEICE Tech. Rep., vol. 110, no. 364, MI2010-103, pp. 115-120, Jan. 2011.
Paper # MI2010-103 
Date of Issue 2011-01-12 (MI) 
ISSN Print edition: ISSN 0913-5685    Online edition: ISSN 2432-6380
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All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
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Conference Information
Committee MI  
Conference Date 2011-01-19 - 2011-01-20 
Place (in Japanese) (See Japanese page) 
Place (in English) Naha-Bunka-Tembusu 
Topics (in Japanese) (See Japanese page) 
Topics (in English) General Medical Imaging 
Paper Information
Registration To MI 
Conference Code 2011-01-MI 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Brain Shape Normalization in Neonatal MR Images 
Sub Title (in English)  
Keyword(1) voxel-based morphometry  
Keyword(2) MR image  
Keyword(3) neonate  
Keyword(4) brain  
Keyword(5) normalization  
Keyword(6) mutual information  
Keyword(7) anterior commissure  
Keyword(8) posterior commisure  
1st Author's Name Aya Hashioka  
1st Author's Affiliation University of Hyogo (Univ. of Hyogo)
2nd Author's Name Syoji Kobashi  
2nd Author's Affiliation University of Hyogo/ WPI Immunology Frontier Research Center, Osaka University (Univ. of Hyogo/ WPI-IFReC)
3rd Author's Name Kei Kuramoto  
3rd Author's Affiliation University of Hyogo/ WPI Immunology Frontier Research Center, Osaka University (Univ. of Hyogo/ WPI-IFReC)
4th Author's Name Yuki Wakata  
4th Author's Affiliation Hyogo College of Medicine (Hyogo College of Medicine)
5th Author's Name Kumiko Ando  
5th Author's Affiliation Hyogo College of Medicine (Hyogo College of Medicine)
6th Author's Name Reiichi Ishikura  
6th Author's Affiliation Hyogo College of Medicine (Hyogo College of Medicine)
7th Author's Name Tomomoto Ishikawa  
7th Author's Affiliation Ishikawa Hospital (Ishikawa Hospital)
8th Author's Name Shozo Hirota  
8th Author's Affiliation Hyogo College of Medicine (Hyogo College of Medicine)
9th Author's Name Yutaka Hata  
9th Author's Affiliation University of Hyogo/ WPI Immunology Frontier Research Center, Osaka University (Univ. of Hyogo/ WPI-IFReC)
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Speaker Author-1 
Date Time 2011-01-20 11:30:00 
Presentation Time 30 minutes 
Registration for MI 
Paper # MI2010-103 
Volume (vol) vol.110 
Number (no) no.364 
Page pp.115-120 
#Pages
Date of Issue 2011-01-12 (MI) 


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