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Paper Abstract and Keywords
Presentation 2010-03-09 10:15
Difference in odor discrimination between presynaptic and postsynaptic inhibition in the Drosophila olfactory circuit
Ryota Satoh, Masafumi Oizumi (Univ. of Tokyo), Hokto Kazama (Harvard Medical School), Masato Okada (Univ. of Tokyo/RIKEN) NC2009-89
Abstract (in Japanese) (See Japanese page) 
(in English) A recent investigation has indicated that lateral presynaptic inhibitory input mediates gain control in the Drosophila antennal lobe. They have shown that the lateral presynaptic inhibitory input to projection neurons (PNs) roughly scales with total feedforward input from olfactory receptor neurons (ORNs). We investigate how this gain control mechanism contributes to the discriminability of odors in responses of PNs by simulating a network model of the Drosophila antennal lobe. To clarify the functional significance of ‘pre’-synaptic inhibitory gain control mechanism, which indirectly inhibits PNs by regulating the release probability of the synapse between ORNs and PNs, we also consider the case that inhibition acts ‘post’-synaptically by directly decreasing the membrane potential of PNs. We first show that the presynaptic global inhibition can sharpen the odour tuning of PNs whereas the postsynaptic global inhibition does not change it. We next demonstrate that the presynaptic gain control enhances the accuracy of odorant discrimination although the postsynaptic gain control only diminishes it. Finally, we discuss the reason why the odor discriminability can be enhanced by this presynaptic gain control mechanism.
Keyword (in Japanese) (See Japanese page) 
(in English) Drosophila / Olfaction / Antennal lobe / Presynaptic inhibition / Postsynaptic inhibition / / /  
Reference Info. IEICE Tech. Rep., vol. 109, no. 461, NC2009-89, pp. 13-18, March 2010.
Paper # NC2009-89 
Date of Issue 2010-03-02 (NC) 
ISSN Print edition: ISSN 0913-5685  Online edition: ISSN 2432-6380
Copyright
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reproduction
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
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Conference Information
Committee NC MBE  
Conference Date 2010-03-09 - 2010-03-11 
Place (in Japanese) (See Japanese page) 
Place (in English) Tamagawa University 
Topics (in Japanese) (See Japanese page) 
Topics (in English) General 
Paper Information
Registration To NC 
Conference Code 2010-03-NC-MBE 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Difference in odor discrimination between presynaptic and postsynaptic inhibition in the Drosophila olfactory circuit 
Sub Title (in English)  
Keyword(1) Drosophila  
Keyword(2) Olfaction  
Keyword(3) Antennal lobe  
Keyword(4) Presynaptic inhibition  
Keyword(5) Postsynaptic inhibition  
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1st Author's Name Ryota Satoh  
1st Author's Affiliation The University of Tokyo (Univ. of Tokyo)
2nd Author's Name Masafumi Oizumi  
2nd Author's Affiliation The University of Tokyo (Univ. of Tokyo)
3rd Author's Name Hokto Kazama  
3rd Author's Affiliation Harvard Medical School (Harvard Medical School)
4th Author's Name Masato Okada  
4th Author's Affiliation The University of Tokyo/RIKEN Brain Science Institute (Univ. of Tokyo/RIKEN)
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Speaker
Date Time 2010-03-09 10:15:00 
Presentation Time 25 
Registration for NC 
Paper # IEICE-NC2009-89 
Volume (vol) IEICE-109 
Number (no) no.461 
Page pp.13-18 
#Pages IEICE-6 
Date of Issue IEICE-NC-2010-03-02 


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