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| Presentation | 2009-12-11 16:35 On a computational method for the extraction of the critical signal transduction pathways out of the large-scale molecular network in the postsynaptic plasticity of striatal medium spiny neurons Yousuke Inui (Osaka Univ), Takashi Tateno (Osaka Univ/JST)  NC2009-68 |
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| Abstract | (in Japanese) | (See Japanese page) |
| (in English) | In this study, we aimed at understanding complex interactions between molecules in a large-scale molecular network in the postsynaptic plasticity of striatal medium spiny neurons. For the first step, to this end, we modeled the network and extracted several critical signal transduction pathways out of it. Our results of model simulation revealed that coincidently increasing dopamine and intracellular calcium concentrations was essential for induction of long-term potentiation. However, our model failed to mimic some experimental phenomena in the literature, which implied, in the next step, that several new pathways should be involved in the network model reported here. | |
| Keyword | (in Japanese) | (See Japanese page) |
| (in English) | striatum / synaptic plasticity / signal transduction / kinetic simulation / / / / | |
| Reference Info. | IEICE Tech. Rep., vol. 109, no. 333, NC2009-68, pp. 31-36, Dec. 2009. | |
| Paper # | NC2009-68 | |
| Date of Issue | 2009-12-04 (NC) | |
| ISSN | Print edition: ISSN 0913-5685 Online edition: ISSN 2432-6380 | |
| Copyright and reproduction |
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034) | |
| Download PDF | NC2009-68 |
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| Conference Information | |
| Committee | NC MBE |
| Conference Date | 2009-12-11 - 2009-12-11 |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
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| Paper Information | |
| Registration To | NC |
| Conference Code | 2009-12-NC-MBE |
| Language | Japanese |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | On a computational method for the extraction of the critical signal transduction pathways out of the large-scale molecular network in the postsynaptic plasticity of striatal medium spiny neurons |
| Sub Title (in English) | |
| Keyword(1) | striatum |
| Keyword(2) | synaptic plasticity |
| Keyword(3) | signal transduction |
| Keyword(4) | kinetic simulation |
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| 1st Author's Name | Yousuke Inui |
| 1st Author's Affiliation | Osaka University (Osaka Univ) |
| 2nd Author's Name | Takashi Tateno |
| 2nd Author's Affiliation | Osaka University/PRESTO, Japan Science and Technology Agency (Osaka Univ/JST) |
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| Speaker | Author-1 |
| Date Time | 2009-12-11 16:35:00 |
| Presentation Time | 25 minutes |
| Registration for | NC |
| Paper # | NC2009-68 |
| Volume (vol) | vol.109 |
| Number (no) | no.333 |
| Page | pp.31-36 |
| #Pages | 6 |
| Date of Issue | 2009-12-04 (NC) |
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