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| Presentation | 2009-10-16 14:50 Algorithm for Finding Minimum Reaction Cut of Metabolic Network Takeyuki Tamura (Kyoto Univ.), Kazuhiro Takemoto (Univ. of Tokyo.), Tatsuya Akutsu (Kyoto Univ.)  COMP2009-36 |
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| Abstract | (in Japanese) | (See Japanese page) |
| (in English) | In this article, we study two problems ReactionCut and MD-ReactionCut for calculating minimum reaction cuts of a metabolic network under a Boolean model. These problems are based on flux balance model and minimal damage model respectively. We show that ReactionCut and MD-ReactionCut are NP-hard even if the maximum outdegree of reaction nodes ($K_{out}$) is one. We also present $O(1.822^n)$, $O(1.959^n)$ and $o(2^n)$ time algorithms for MD-ReactionCut with $K_{out}=2, 3, k$ respectively where $n$ is the number of reaction nodes and $k$ is a constant. The same algorithms also work for ReactionCut if there is no cycle. |
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| Keyword | (in Japanese) | (See Japanese page) |
| (in English) | Metabolic network / Reaction cut / Boolean model / Robustness / / / / | |
| Reference Info. | IEICE Tech. Rep., vol. 109, no. 235, COMP2009-36, pp. 27-34, Oct. 2009. | |
| Paper # | COMP2009-36 | |
| Date of Issue | 2009-10-09 (COMP) | |
| ISSN | Print edition: ISSN 0913-5685 Online edition: ISSN 2432-6380 | |
| Copyright and reproduction |
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034) | |
| Download PDF | COMP2009-36 |
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| Conference Information | |
| Committee | COMP |
| Conference Date | 2009-10-16 - 2009-10-16 |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | Tohoku University |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
| Paper Information | |
| Registration To | COMP |
| Conference Code | 2009-10-COMP |
| Language | Japanese |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Algorithm for Finding Minimum Reaction Cut of Metabolic Network |
| Sub Title (in English) | |
| Keyword(1) | Metabolic network |
| Keyword(2) | Reaction cut |
| Keyword(3) | Boolean model |
| Keyword(4) | Robustness |
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| 1st Author's Name | Takeyuki Tamura |
| 1st Author's Affiliation | Kyoto University (Kyoto Univ.) |
| 2nd Author's Name | Kazuhiro Takemoto |
| 2nd Author's Affiliation | The University of Tokyo (Univ. of Tokyo.) |
| 3rd Author's Name | Tatsuya Akutsu |
| 3rd Author's Affiliation | Kyoto University (Kyoto Univ.) |
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| Speaker | Author-1 |
| Date Time | 2009-10-16 14:50:00 |
| Presentation Time | 35 minutes |
| Registration for | COMP |
| Paper # | COMP2009-36 |
| Volume (vol) | vol.109 |
| Number (no) | no.235 |
| Page | pp.27-34 |
| #Pages | 8 |
| Date of Issue | 2009-10-09 (COMP) |
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