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Paper Abstract and Keywords
Presentation 2009-06-26 13:30
Mechanisms involved in the regulation of ATP release during ischemia and ischemia/reperfusion injury in cultured cardiomyocytes
Satohiko Kunugi, Daisuke Matsuyama, Sadahiro Iwabuchi, Koichi Kawahara (Hokkaido Univ.) MBE2009-13
Abstract (in Japanese) (See Japanese page) 
(in English) It is known that pannexin or connexin hemichannels and maxi-anion channels work as primary ATP release pathways in many kinds of cells. Although maxi-anion channels are reported as an ATP release pathway during early ischemia, the exact mechanisms responsible for ATP release during ischemia and the relationships between ATP release and ischemia/reperfusion injury are not fully understood at present. We have recently demonstrated that nitric monoxide (NO) generated in cardiomyocytes during ischemia possibly contributes to maintaining the concentration of intracellular ATP. This study aims at elucidating the intracellular signal transduction mechanisms involved in the regulation of ATP release during ischemia in cultured cardiomyocytes.
Keyword (in Japanese) (See Japanese page) 
(in English) ischemia / reperfusion / ATP / maxi-anion channel / pannexin hemichannel / connexin hemichannel / /  
Reference Info. IEICE Tech. Rep., vol. 109, no. 106, MBE2009-13, pp. 1-4, June 2009.
Paper # MBE2009-13 
Date of Issue 2009-06-19 (MBE) 
ISSN Print edition: ISSN 0913-5685  Online edition: ISSN 2432-6380
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
Download PDF MBE2009-13

Conference Information
Committee MBE  
Conference Date 2009-06-26 - 2009-06-26 
Place (in Japanese) (See Japanese page) 
Place (in English) Hokkaido Univ. 
Topics (in Japanese) (See Japanese page) 
Topics (in English) ME in general 
Paper Information
Registration To MBE 
Conference Code 2009-06-MBE 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Mechanisms involved in the regulation of ATP release during ischemia and ischemia/reperfusion injury in cultured cardiomyocytes 
Sub Title (in English)  
Keyword(1) ischemia  
Keyword(2) reperfusion  
Keyword(3) ATP  
Keyword(4) maxi-anion channel  
Keyword(5) pannexin hemichannel  
Keyword(6) connexin hemichannel  
1st Author's Name Satohiko Kunugi  
1st Author's Affiliation Hokkaido University (Hokkaido Univ.)
2nd Author's Name Daisuke Matsuyama  
2nd Author's Affiliation Hokkaido University (Hokkaido Univ.)
3rd Author's Name Sadahiro Iwabuchi  
3rd Author's Affiliation Hokkaido University (Hokkaido Univ.)
4th Author's Name Koichi Kawahara  
4th Author's Affiliation Hokkaido University (Hokkaido Univ.)
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Date Time 2009-06-26 13:30:00 
Presentation Time 25 
Registration for MBE 
Paper # IEICE-MBE2009-13 
Volume (vol) IEICE-109 
Number (no) no.106 
Page pp.1-4 
#Pages IEICE-4 
Date of Issue IEICE-MBE-2009-06-19 

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