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Paper Abstract and Keywords
Presentation 2009-01-19 10:30
[Special Invited Talk] Molecular Imaging at National Taiwan University
Pai-Chi Li (National Taiwan Univ.)
Abstract (in Japanese) (See Japanese page) 
(in English) Molecular imaging has attracted widespread research attention. It can be generally defined as any measurement of events occurring at the molecular level in a spatially and temporally resolved manner. In other words, it is the characterization and measurements of biological processes in living animals, model systems, and humans at the molecular level using remote imaging detectors. Recent interest in the development of novel strategies for the production of nanoparticles also helps accelerate the development of molecular imaging and it is being pursued in all areas of noninvasive medical imaging, including nuclear medicine, magnetic resonance imaging, ultrasound and optics. Each imaging modality has unique advantages and disadvantages, and ultimately the best approach is dependent upon the question being addressed. It is important to note that one major premise of molecular imaging is that it is not defined by the imaging technologies that underpin acquisition of the final image, but rather is driven by the underlying biological questions. In this talk, we will overview the research activities of molecular imaging at National Taiwan University. In addition to a general introduction, recent development of ultrasonic molecular imaging and photoacoustic molecular imaging will also be specifically described.

Ultrasonic imaging and photoacoustic imaging provide unique advantages and also face specific challenges. Ultrasonic molecular imaging, on one hand, is based on mechanical properties of the image object and many unique applications have been developed. With the aid of superior spatial resolution, high frequency ultrasound imaging has also evolved from clinical anatomical imaging to probing of molecular processes on small animals for pre-clinical research. Photoacoustic imaging, on the other hand, combines advantages of both optics and acoustics. Research developments in imaging physics and instrumentation have also found promising biomedical applications. In addition, microbubbles typically used in ultrasonic imaging as the contrast agent present unique mechanical properties and the associated acoustic cavitation has been exploited for therapeutic purposes. Similarly, gold nanoparticles are found to be an ideal contrast agent for photoacoustic imaging for its bioconjugation capabilities and presumed safety. The efficient light absorption of gold nanoparticles and abilities to tune their optical properties have also led to new photothermal therapy techniques. We will review our efforts in physics, instrumentation and applications of ultrasonic and photoacoustic imaging. New development in combined diagnosis with therapy for both modalities will also be introduced, with a discussion on possible synergy and the technical difficulties that each modality faces, before critical clinical impact can be made.
Keyword (in Japanese) (See Japanese page) 
(in English) molecular imaging / National Taiwan University / ultrasonic imaging / photoacoustic imaging / / / /  
Reference Info. IEICE Tech. Rep., vol. 108, no. 385, MI2008-56, pp. 3-3, Jan. 2009.
Paper # MI2008-56 
Date of Issue 2009-01-12 (MI) 
ISSN Print edition: ISSN 0913-5685  Online edition: ISSN 2432-6380

Conference Information
Committee MI  
Conference Date 2009-01-19 - 2009-01-21 
Place (in Japanese) (See Japanese page) 
Place (in English) National Taiwan University 
Topics (in Japanese) (See Japanese page) 
Topics (in English) Medical Imaging 
Paper Information
Registration To MI 
Conference Code 2009-01-MI 
Language English 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Molecular Imaging at National Taiwan University 
Sub Title (in English)  
Keyword(1) molecular imaging  
Keyword(2) National Taiwan University  
Keyword(3) ultrasonic imaging  
Keyword(4) photoacoustic imaging  
1st Author's Name Pai-Chi Li  
1st Author's Affiliation National Taiwan University (National Taiwan Univ.)
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Date Time 2009-01-19 10:30:00 
Presentation Time 20 
Registration for MI 
Paper # IEICE-MI2008-56 
Volume (vol) IEICE-108 
Number (no) no.385 
Page p.3 
#Pages IEICE-1 
Date of Issue IEICE-MI-2009-01-12 

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