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| Presentation | 2009-01-19 11:45 MR Spectroscopy of Skeletal Muscle in Male Patients with Obstructive Sleep Apnea Chih-Wei Yu, Tiffany Ting-Fang Shih, Meng-Yueh Chien (National Taiwan Univ.), Peilin Lee (National Taiwan Hospital), Chao-Yu Hsu, Bang-Bin Chen (National Taiwan Univ.), Yi-Miau Chen (National Taiwan Hospital)  MI2008-61 |
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| Abstract | (in Japanese) | (See Japanese page) |
| (in English) | PURPOSE To investigate extra- (EMCL) and intramyocellular (IMCL) lipid changes in skeletal muscle by means of proton magnetic resonance spectroscopy (1H-MRS) in male patients with obstructive sleep apnea (OSA). MATERIAL AND METHODS Eighteen male patients with documented OSA and eighteen age- and BMI-matched male volunteers (age ranged 50.7 +/- 5.7 vs. 50.4 +/- 6.9 years; BMI ranged 25.9 +/- 2.9 vs. 25.7 +/- 2.7, respectively) were consecutively accrued in this study. 1H-MRS of the right adductor magnus muscle was performed on a 1.5T clinical MR scanner. EMCL fraction was defined as the ratio of the integration of EMCL methylene (-CH2) and EMCL methyl (-CH3) to creatine resonances. IMCL fraction was defined as the ratio of the integration of IMCL (-CH2) and IMCL (-CH3) to creatine resonances. The strength, expressed by maximum voluntary contractions (MVC), and endurance of the thigh muscles were measured by using an isokinetic dynamometer (Cybex 6000). Variables of both groups were compared using paired sample t test. RESULTS OSA patients had significantly lower value of IMCL fraction (10.3 vs. 14.1, P = 0.03) and EMCL fraction (14.1 vs. 24.7, P = 0.01) when compared with normal volunteers. OSA patients had significantly lower value of muscle strength (134.0 vs. 158.7, P < 0.001) and endurance (43.6% vs. 61.6%, P < 0.001) when compared with normal volunteers. No significant correlation between the IMCL or EMCL fraction and the muscle strength or endurance. CONCLUSION 1H-MRS demonstrated both decreased IMCL and EMCL content in male patients with OSA. No significant correlation between muscle lipid measurement and its function. |
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| Keyword | (in Japanese) | (See Japanese page) |
| (in English) | proton magnetic resonance spectroscopy (1H-MRS) / obstructive sleep apnea (OSA) / skeletal muscle / lipid / / / / | |
| Reference Info. | IEICE Tech. Rep., vol. 108, no. 385, MI2008-61, pp. 21-24, Jan. 2009. | |
| Paper # | MI2008-61 | |
| Date of Issue | 2009-01-12 (MI) | |
| ISSN | Print edition: ISSN 0913-5685 Online edition: ISSN 2432-6380 | |
| Copyright and reproduction |
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034) | |
| Download PDF | MI2008-61 |
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| Conference Information | |
| Committee | MI |
| Conference Date | 2009-01-19 - 2009-01-21 |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | National Taiwan University |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | Medical Imaging |
| Paper Information | |
| Registration To | MI |
| Conference Code | 2009-01-MI |
| Language | English |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | MR Spectroscopy of Skeletal Muscle in Male Patients with Obstructive Sleep Apnea |
| Sub Title (in English) | |
| Keyword(1) | proton magnetic resonance spectroscopy (1H-MRS) |
| Keyword(2) | obstructive sleep apnea (OSA) |
| Keyword(3) | skeletal muscle |
| Keyword(4) | lipid |
| Keyword(5) | |
| Keyword(6) | |
| Keyword(7) | |
| Keyword(8) | |
| 1st Author's Name | Chih-Wei Yu |
| 1st Author's Affiliation | National Taiwan University (National Taiwan Univ.) |
| 2nd Author's Name | Tiffany Ting-Fang Shih |
| 2nd Author's Affiliation | National Taiwan University (National Taiwan Univ.) |
| 3rd Author's Name | Meng-Yueh Chien |
| 3rd Author's Affiliation | National Taiwan University (National Taiwan Univ.) |
| 4th Author's Name | Peilin Lee |
| 4th Author's Affiliation | National Taiwan University Hospital (National Taiwan Hospital) |
| 5th Author's Name | Chao-Yu Hsu |
| 5th Author's Affiliation | National Taiwan University (National Taiwan Univ.) |
| 6th Author's Name | Bang-Bin Chen |
| 6th Author's Affiliation | National Taiwan University (National Taiwan Univ.) |
| 7th Author's Name | Yi-Miau Chen |
| 7th Author's Affiliation | National Taiwan University Hospital (National Taiwan Hospital) |
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| Speaker | Author-1 |
| Date Time | 2009-01-19 11:45:00 |
| Presentation Time | 10 minutes |
| Registration for | MI |
| Paper # | MI2008-61 |
| Volume (vol) | vol.108 |
| Number (no) | no.385 |
| Page | pp.21-24 |
| #Pages | 4 |
| Date of Issue | 2009-01-12 (MI) |
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