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Paper Abstract and Keywords
Presentation 2009-01-19 11:45
MR Spectroscopy of Skeletal Muscle in Male Patients with Obstructive Sleep Apnea
Chih-Wei Yu, Tiffany Ting-Fang Shih, Meng-Yueh Chien (National Taiwan Univ.), Peilin Lee (National Taiwan Hospital), Chao-Yu Hsu, Bang-Bin Chen (National Taiwan Univ.), Yi-Miau Chen (National Taiwan Hospital)
Abstract (in Japanese) (See Japanese page) 
(in English) PURPOSE
To investigate extra- (EMCL) and intramyocellular (IMCL) lipid changes in skeletal muscle by means of proton magnetic resonance spectroscopy (1H-MRS) in male patients with obstructive sleep apnea (OSA).

MATERIAL AND METHODS
Eighteen male patients with documented OSA and eighteen age- and BMI-matched male volunteers (age ranged 50.7 +/- 5.7 vs. 50.4 +/- 6.9 years; BMI ranged 25.9 +/- 2.9 vs. 25.7 +/- 2.7, respectively) were consecutively accrued in this study. 1H-MRS of the right adductor magnus muscle was performed on a 1.5T clinical MR scanner. EMCL fraction was defined as the ratio of the integration of EMCL methylene (-CH2) and EMCL methyl (-CH3) to creatine resonances. IMCL fraction was defined as the ratio of the integration of IMCL (-CH2) and IMCL (-CH3) to creatine resonances. The strength, expressed by maximum voluntary contractions (MVC), and endurance of the thigh muscles were measured by using an isokinetic dynamometer (Cybex 6000). Variables of both groups were compared using paired sample t test.

RESULTS
OSA patients had significantly lower value of IMCL fraction (10.3 vs. 14.1, P = 0.03) and EMCL fraction (14.1 vs. 24.7, P = 0.01) when compared with normal volunteers. OSA patients had significantly lower value of muscle strength (134.0 vs. 158.7, P < 0.001) and endurance (43.6% vs. 61.6%, P < 0.001) when compared with normal volunteers. No significant correlation between the IMCL or EMCL fraction and the muscle strength or endurance.

CONCLUSION
1H-MRS demonstrated both decreased IMCL and EMCL content in male patients with OSA. No significant correlation between muscle lipid measurement and its function.
Keyword (in Japanese) (See Japanese page) 
(in English) proton magnetic resonance spectroscopy (1H-MRS) / obstructive sleep apnea (OSA) / skeletal muscle / lipid / / / /  
Reference Info. IEICE Tech. Rep., vol. 108, no. 385, MI2008-61, pp. 21-24, Jan. 2009.
Paper # MI2008-61 
Date of Issue 2009-01-12 (MI) 
ISSN Print edition: ISSN 0913-5685  Online edition: ISSN 2432-6380

Conference Information
Committee MI  
Conference Date 2009-01-19 - 2009-01-21 
Place (in Japanese) (See Japanese page) 
Place (in English) National Taiwan University 
Topics (in Japanese) (See Japanese page) 
Topics (in English) Medical Imaging 
Paper Information
Registration To MI 
Conference Code 2009-01-MI 
Language English 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) MR Spectroscopy of Skeletal Muscle in Male Patients with Obstructive Sleep Apnea 
Sub Title (in English)  
Keyword(1) proton magnetic resonance spectroscopy (1H-MRS)  
Keyword(2) obstructive sleep apnea (OSA)  
Keyword(3) skeletal muscle  
Keyword(4) lipid  
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1st Author's Name Chih-Wei Yu  
1st Author's Affiliation National Taiwan University (National Taiwan Univ.)
2nd Author's Name Tiffany Ting-Fang Shih  
2nd Author's Affiliation National Taiwan University (National Taiwan Univ.)
3rd Author's Name Meng-Yueh Chien  
3rd Author's Affiliation National Taiwan University (National Taiwan Univ.)
4th Author's Name Peilin Lee  
4th Author's Affiliation National Taiwan University Hospital (National Taiwan Hospital)
5th Author's Name Chao-Yu Hsu  
5th Author's Affiliation National Taiwan University (National Taiwan Univ.)
6th Author's Name Bang-Bin Chen  
6th Author's Affiliation National Taiwan University (National Taiwan Univ.)
7th Author's Name Yi-Miau Chen  
7th Author's Affiliation National Taiwan University Hospital (National Taiwan Hospital)
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Speaker
Date Time 2009-01-19 11:45:00 
Presentation Time 10 
Registration for MI 
Paper # IEICE-MI2008-61 
Volume (vol) IEICE-108 
Number (no) no.385 
Page pp.21-24 
#Pages IEICE-4 
Date of Issue IEICE-MI-2009-01-12 


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