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Paper Abstract and Keywords
Presentation 2005-06-17 17:30
Fundamental study for developing the drug delivery system targeting the heart
Daisuke Matsuyama, Takeru Naiki (Hokkaido Univ.)
Abstract (in Japanese) (See Japanese page) 
(in English) We designed a drug delivery system (DDS) that the careers release the drug mainly in the cardiac capillary blood vessels. The blood in these blood vessels flows backward at the systolic period as the cardiac muscle contracts the capillary vessels in the heart. There are not so much backflows in the capillary blood vessels in other organs. Thus we considered that the career, which releases drug depending on the amount of flow fluctuations, could be use for the DDS for targeting the heart. To verify this hypothesis, we must manufacture the career first, and investigate the drug accumulations in the heart of experimental animals. In the present report, we used alginate gel as the DDS career, measured the amount of drug releases in several flow conditions, and discussed whether this career could be available for inspecting our hypothesis.
Keyword (in Japanese) (See Japanese page) 
(in English) Drug delivery system / Heart / Alginate gel / Blood flow / Shear stress / / /  
Reference Info. IEICE Tech. Rep., vol. 105, no. 122, MBE2005-21, pp. 41-44, June 2005.
Paper # MBE2005-21 
Date of Issue 2005-06-10 (MBE) 
ISSN Print edition: ISSN 0913-5685  Online edition: ISSN 2432-6380
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Conference Information
Committee MBE  
Conference Date 2005-06-17 - 2005-06-17 
Place (in Japanese) (See Japanese page) 
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Paper Information
Registration To MBE 
Conference Code 2005-06-MBE 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Fundamental study for developing the drug delivery system targeting the heart 
Sub Title (in English)  
Keyword(1) Drug delivery system  
Keyword(2) Heart  
Keyword(3) Alginate gel  
Keyword(4) Blood flow  
Keyword(5) Shear stress  
1st Author's Name Daisuke Matsuyama  
1st Author's Affiliation Hokkaido University (Hokkaido Univ.)
2nd Author's Name Takeru Naiki  
2nd Author's Affiliation Hokkaido University (Hokkaido Univ.)
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Date Time 2005-06-17 17:30:00 
Presentation Time 25 
Registration for MBE 
Paper # IEICE-MBE2005-21 
Volume (vol) IEICE-105 
Number (no) no.122 
Page pp.41-44 
#Pages IEICE-4 
Date of Issue IEICE-MBE-2005-06-10 

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