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Paper Abstract and Keywords
Presentation 2004-10-15 15:25
A Local Search Algorithm for Barrier Heights Estimation in DNA computing
Tsutomu Takeda, Hirotaka Ono, Kunihiko Sadakane, Masafumi Yamashita (Kyushu Univ.)
Abstract (in Japanese) (See Japanese page) 
(in English) DNA computing is a new computing paradigm utilizing the transitions of DNA
molecules as computation. In the context, the sequence design problem has been studied to design DNA molecules whose transitions are suitable for computation. In this paper, we consider the problem of estimating the height of the energy barrier that plays an important role in the sequence design. The barrier height depends on intermediate structures in all transition paths. Unfortunately, the number of intermediate structures is exponential of the sequence length, and the exhaustive search is not practical. We propose a fast heuristic approximation algorithm based on the local search. Computational experiments show that our algorithm finds good solutions as the exitsting exact algorithm in short time.
Keyword (in Japanese) (See Japanese page) 
(in English) DNA computing / energy barrier height / local search algorithm / / / / /  
Reference Info. IEICE Tech. Rep., vol. 104, no. 339, COMP2004-49, pp. 41-46, Oct. 2004.
Paper # COMP2004-49 
Date of Issue 2004-10-07 (COMP) 
ISSN Print edition: ISSN 0913-5685
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Conference Information
Committee COMP  
Conference Date 2004-10-14 - 2004-10-15 
Place (in Japanese) (See Japanese page) 
Place (in English) Tohoku University 
Topics (in Japanese) (See Japanese page) 
Topics (in English)  
Paper Information
Registration To COMP 
Conference Code 2004-10-COMP 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) A Local Search Algorithm for Barrier Heights Estimation in DNA computing 
Sub Title (in English)  
Keyword(1) DNA computing  
Keyword(2) energy barrier height  
Keyword(3) local search algorithm  
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1st Author's Name Tsutomu Takeda  
1st Author's Affiliation Kyushu University (Kyushu Univ.)
2nd Author's Name Hirotaka Ono  
2nd Author's Affiliation Kyushu University (Kyushu Univ.)
3rd Author's Name Kunihiko Sadakane  
3rd Author's Affiliation Kyushu University (Kyushu Univ.)
4th Author's Name Masafumi Yamashita  
4th Author's Affiliation Kyushu University (Kyushu Univ.)
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Speaker Author-1 
Date Time 2004-10-15 15:25:00 
Presentation Time 30 minutes 
Registration for COMP 
Paper # COMP2004-49 
Volume (vol) vol.104 
Number (no) no.339 
Page pp.41-46 
#Pages
Date of Issue 2004-10-07 (COMP) 


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