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Paper Abstract and Keywords
Presentation 2008-09-26 10:00
Image analysis of higher-order nuclear architecture formed by a DNA recombinational repair protein RAD51
Akira Asano, Kazuteru Kono, Satoshi Tashiro (Hiroshima Univ.)
Abstract (in Japanese) (See Japanese page) 
(in English) It has been recently shown that the cell nucleus is a highly compartmentalized organelle with chromosome and chromatin domains formed by DNA. Although nuclear proteins also have been speculated to form higher order structure in the compartment between chromatin domains, how the formation of interchromatin compartment is organized is still unclear. We have previously shown that RAD51, a recombinational repair protein, forms nuclear foci, typically during S phase, and accumulates at sites of DNA double-strand breaks. We found that over-expressed RAD51 forms bundle-like structures in the nucleus. Since the structures are formed in the interchromatin compartment, we decided to study the influence of chromatin structure to the organization of interchromatin compartment. For this purpose, we examined the change of the RAD51 bundle-like structure shape after de-condensation of chromatin by the treatment with trichostatin A (TSA), a histone deacetylase inhibitor. The complexity of the GFP-RAD51 bundle-like structures was analyzed quantitatively using digital image processing methods.
Keyword (in Japanese) (See Japanese page) 
(in English) recombinatorial repair protein / chromatin structure / bioimaging / / / / /  
Reference Info. IEICE Tech. Rep., vol. 108, no. 213, SIP2008-97, pp. 43-46, Sept. 2008.
Paper # SIP2008-97 
Date of Issue 2008-09-18 (SIP, SIS) 
ISSN Print edition: ISSN 0913-5685  Online edition: ISSN 2432-6380

Conference Information
Committee SIS SIP IPSJ-AVM  
Conference Date 2008-09-25 - 2008-09-26 
Place (in Japanese) (See Japanese page) 
Place (in English) Tobata Campus, Kyushu Institute of Technology 
Topics (in Japanese) (See Japanese page) 
Topics (in English) Signal Processing, Intelligent Multimedia Systems, etc. 
Paper Information
Registration To SIP 
Conference Code 2008-09-SIS-SIP-AVM 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Image analysis of higher-order nuclear architecture formed by a DNA recombinational repair protein RAD51 
Sub Title (in English)  
Keyword(1) recombinatorial repair protein  
Keyword(2) chromatin structure  
Keyword(3) bioimaging  
1st Author's Name Akira Asano  
1st Author's Affiliation Hiroshima University (Hiroshima Univ.)
2nd Author's Name Kazuteru Kono  
2nd Author's Affiliation Hiroshima University (Hiroshima Univ.)
3rd Author's Name Satoshi Tashiro  
3rd Author's Affiliation Hiroshima University (Hiroshima Univ.)
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Date Time 2008-09-26 10:00:00 
Presentation Time 25 
Registration for SIP 
Paper # IEICE-SIP2008-97,IEICE-SIS2008-32 
Volume (vol) IEICE-108 
Number (no) no.213(SIP), no.214(SIS) 
Page pp.43-46 
#Pages IEICE-4 
Date of Issue IEICE-SIP-2008-09-18,IEICE-SIS-2008-09-18 

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